Project Grant RF1NS124848

Award Date 5/1/22
Completion Date 4/30/25
Dollars Obligated $4.8M
Funding Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
California, USA
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This $1,707,089 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will fund research at Northwestern University to investigate synergistic treatments for dementia with Lewy bodies (DLB) and Parkinson's disease-dementia (PDD). The key focus is enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity to reduce the accumulation and aggregation of alpha-synuclein, a hallmark of these neurodegenerative synucleinopathies. The...
The National Institute on Aging (NIA) awarded a $7,704,350 Project Grant (CFDA 93.866 - Aging Research) to the University of Pennsylvania to support research aimed at understanding the mechanisms underlying the heterogeneity of cognitive outcomes in Lewy body disorders (LBD), including Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease with Lewy bodies. The 5-year award, effective September 15, 2024, will fund four synergistic research projects investigating the roles of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides funding to Brigham & Women's Hospital, a subsidiary of Partners Healthcare System, to conduct research on distinguishing normal and pathological phosphorylation of the protein alpha-synuclein (a-synuclein) in Lewy body dementia. The $223,750 award, effective August 15, 2024 through April 30, 2026, will support two key objectives: 1) comparing the biochemical properties of physiological...
This federal Project Grant award, provided by the National Institute on Aging (NIA) under CFDA 93.866 Aging Research, aims to use magnetic resonance imaging (MRI) and positron emission tomography (PET) to evaluate the sequence and topography of synaptic, white matter microstructural, and volumetric changes that correspond to prodromal and manifest stages of Lewy body dementia (LBD). The $1,510,600 award will fund a study to recruit 160 participants, including 120 with risk factors for LBD and...
The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $560,489 Project Grant to the University of Florida's Division of Sponsored Research. The grant, awarded on Jul 15, 2024, supports research to investigate the intersection of the GBA and LRRK2 genes in Lewy body dementia (LBD). Specifically, the project will use induced pluripotent stem cell-derived neurons, including isogenic cells with GBA1 mutations, to examine the influence of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $655,638 to the University of Denver to develop and test synthetic protein mimetics as potential therapeutics for Lewy body dementia (LBD). The key products and services to be delivered under this award include: Optimization and testing of the pharmaceutical properties of the oligopyridylamide (OP) synthetic protein mimetics, including evaluating their absorption, distribution,...
This federal Project Grant award, with a total funding of $163,750.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award aims to identify innovative drug candidates for treating Parkinson's disease (PD) and dementia with Lewy bodies (DLB) related to mutations in the GBA1 gene. Key products and services to be delivered include: Screening of...
The National Institutes of Health National Institute on Aging awarded $3,521,744 under the Aging Research federal grant program (CFDA 93.866) to Rutgers, The State University of New Jersey for its project titled "SINGLE-NUCLEI MULTIOMIC ANALYSIS OF DLB PROGRESSION." The project aims to analyze changes in post-mortem brain tissue across stages of dementia with Lewy bodies progression using single-nuclei multi-omic techniques. Specifically, the awardee will conduct neuropathological...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,253,665.00 in funding to Mayo Clinic Jacksonville to investigate the underlying disease mechanisms of Lewy body dementia (LBD) associated with the APOE4 genetic isoform. The research aims to utilize human postmortem brain samples, genetically engineered mouse models, and human induced pluripotent stem cell-derived organoid models to elucidate the role of APOE4 in the development of...
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This three-year, $4.766 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, aims to clarify the neuropathological, molecular, and genetic differences between Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) through the Aging Research grant program (CFDA 93.866).

The J. David Gladstone Institutes will use digital pathology, artificial intelligence, single-nuclei RNA sequencing, and spatial transcriptomics on brain tissue samples to distinguish PDD and DLB at the molecular level. Sub-awards will support mass spectrometry and immunoblotting by Dr. Hilal Lashuel at the Brain Mind Institute, EPFL, to analyze alpha-synuclein post-translational modifications in the diseases. Genetic data analysis will be conducted by Dr. Brasa at the Van Andel Research Institute on over 800 PDD cases. Neuropathological studies using digital pathology and deep learning tools will be performed by Dr. Laura Parkkinen at ST Benet's Hall, Oxford. Results aim to clarify differences in the diseases, identify genetic determinants, and pave the way for targeted diagnostics and therapeutics for Lewy body dementias.

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