Project Grant RF1NS143175
- This Project Grant award of $414,191 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research by Drexel University investigating the relationship between structural variations in alpha-synuclein (α-syn) protein fibrils and the development of distinct neurodegenerative synucleinopathies such as Lewy body dementia, Parkinson's disease, and multiple system atrophy....
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA Program 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will provide $2,280,379 to the Regents of the University of Michigan to develop novel nanobody-based agents that can target pathogenic alpha-synuclein to block its cell-to-cell transmission. The grant aims to characterize these nanobody-based agents and assess their in vitro and in...
- This $2,192,716 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) aims to understand the role of serine-129 phosphorylation in the aggregation and spreading of α-synuclein pathology associated with Parkinson's disease, dementia with Lewy bodies, and related synucleinopathies. The project leverages novel serine-129 phospho-deficient and...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,178,675 to investigate the spatial organization and conformational ensembles of alpha-synuclein (a-syn) amyloids inside cells. The project aims to identify the prevalent a-syn amyloid conformations and their abundances in biological settings, which could enhance understanding of amyloid propagation and aid in identifying biologically relevant structures. Key objectives include...
- This $2,069,215 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by Case Western Reserve University to investigate the role of the beta-arrestin2-LMBRD2 pathway in the transmission and toxicity of pathological alpha-synuclein, which is a defining hallmark of Lewy body diseases such as Parkinson's disease and dementia with Lewy bodies. The research will utilize cellular and animal models to study the mechanisms by which beta-arrestin2...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $2,723,954.00 to the University of Alabama at Birmingham (UAB) from June 1, 2025 to May 31, 2027. The grant supports research focused on understanding the effects of 14-3-3θ protein phosphorylation on vesicular transport and alpha-synuclein aggregation, which are key mechanisms...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $732,992 to Virginia Commonwealth University to elucidate the role of cholinergic degeneration in cognitive fluctuations (CF) in Lewy body dementia (LBD). The project aims to determine the association between cholinergic degeneration and CF in LBD, using neuroimaging techniques...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $2,234,905.00 in funding to The University of Iowa to support research aimed at understanding the underlying mechanisms responsible for cognitive fluctuations in Lewy body disorders (LBD). The project will use mouse models to evaluate how the accumulation of...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to establish the role of alpha-synuclein-mediated membrane permeabilization in the spread of alpha-synuclein aggregates related to Parkinson's disease and related dementias. The $406,260 award to Purdue University will leverage fluorescence lifetime imaging microscopy...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify changes in synaptic vesicle-binding of alpha-synuclein as an early biomarker for Parkinson's disease (PD) and Alzheimer's disease related dementias (ADRD). The $793,535 award, with a project period from December 1, 2024 to November 30, 2029, will fund studies...
The $2,674,385 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research by Colorado State University (CSU) to investigate the structure-function relationship for alpha-synuclein (α-syn) protein strains and their impact on the clinical presentation of Lewy body dementia (LBD) and multiple system atrophy (MSA). The research aims to overcome key obstacles in the field by leveraging recent advances from the research team to study how α-syn protein structure affects cognitive and motor impairment in these synucleinopathies. The objective is to establish the first structure-function relationship for a prion-like protein, which will yield fundamental discoveries about the role of protein strains in driving disease phenotypes. The award period runs from August 15, 2025 to July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.7m | 8/12/25 |