Project Grant RF1NS143014
- This $412,751 Project Grant, awarded on August 15, 2024 by the National Institute on Aging (CFDA 93.866 - Aging Research), will fund research by The Trustees of Columbia University in the City of New York to study protein turnover alterations in the aging brain. The project aims to: (I) study the stoichiometry of the ribosome and proteasome; (II) measure changes in protein complex composition; (III) reveal how aging affects protein interaction state turnover; and (IV) address the effects of...
- This $784,596 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northeastern University supports comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease and tauopathy models. The project aims to develop a proteogenomic pipeline to globally characterize disease-associated proteins with amino acid substitutions, alternative isoforms, post-translational modifications, and proteolytic cleavages across multiple brain...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $478,624 Project Grant to President and Fellows of Harvard College (Harvard Medical School) to develop cross-platform fluorescent reporters for measuring the activities of the 26S proteasome and VCP/p97 complexes. These master regulators broadly control ubiquitin-dependent protein breakdown, which is closely associated with aging and age-related pathologies such as Alzheimer's disease...
- This Project Grant award of $100,012.00 from the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), supports research at the University of Washington focused on understanding the role of disruptions to nuclear proteostasis machinery as drivers of neurodegeneration in dementia. The research aims to investigate how disruptions to nuclear pore complexes, nucleocytoplasmic transport, nuclear speckles, and the nuclear ubiquitin proteasome system...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This Project Grant award of $328,000 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports the Alzheimer's Disease Organelle Proteome Task (ADOPT) pilot phase. The interdisciplinary research team, led by Drs. Biao Wang and Danielle Swaney at the University of California, San Francisco, will use a genetic organelle tagging approach to rapidly purify lysosomes from neurons in wild-type and Alzheimer's disease mouse models. A suite of mass spectrometry experiments will then...
- This $3,360,074 federal Project Grant was awarded on September 15, 2025 by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866). The grant is funding research led by the University of Pennsylvania to develop short RNA therapeutics that can combat TDP-43 proteinopathy, a key pathological feature of several devastating neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. The research aims to...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This $6,925,230 Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project at The Trustees of Columbia University in the City of New York to develop a "Multi-Organ Chart of Personalized Susceptibility to Alzheimer's Disease and Aging." The overarching goal is to use large-scale multi-omics, multi-organ biomedical data, advanced artificial intelligence/machine learning, and computational...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,275,512 to The Regents of the University of California, San Francisco (UCSF) to conduct research on understanding how changes in progranulin (PGRN) protein species impact the accumulation of the TDP-43 protein, which is associated with neurodegenerative disorders like Alzheimer's disease and frontotemporal dementia. The research aims to elucidate the role of lysosomes and lysosomal...
This $3,145,300 federal Project Grant award was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate how the ubiquitin-proteasome system (UPS), specifically the proteasome complexes, are affected in Alzheimer's disease (AD), progressive supranuclear palsy (PSP), and Parkinson's disease. The research aims to elucidate the regulation of the proteasome complex, a key component of protein homeostasis, and its potential role in the pathogenesis of neurodegenerative diseases. The award was granted to The Trustees of Columbia University in the City of New York, Health Sciences Division, and the project will be conducted from Aug 1, 2025 through Jul 31, 2029. The research will utilize integrated multi-omics approaches combined with biochemical and functional studies to understand how proteasome dysfunction may contribute to the accumulation and aggregation of disease-specific proteins in these neurodegenerative conditions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 7/31/25 |