This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rutgers, The State University of New Jersey aims to investigate how Alzheimer's disease (AD) pathogenesis interferes with synaptic autophagy, and whether targeting synaptic autophagy can be neuroprotective in an AD mouse model. The $628,000 grant, awarded on January 1, 2025, will utilize primary hippocampal cell cultures and mouse models to determine the disruption of autophagic processing...
This federal Project Grant award, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), is funding research to develop an innovative nanotechnology approach to interrupt the inflammatory communication between glial cells that exacerbates the progression of Alzheimer's disease (AD). The $445,625 award to Rutgers, The State University will be used to: 1) elucidate how scavenger receptor-targeted nanoparticles can ameliorate the pathological glial responses driven by fibrillar...
This federal Project Grant award of $795,436 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rutgers The State University of New Jersey supports a study to elucidate the role of the glycoproteome in Alzheimer's disease and related disorders (AD/ADRD). The research aims to identify glycopeptiforms related to AD/ADRD pathologies and clinical traits, test whether glycopeptiforms link an active lifestyle with brain health, and characterize the genetic architecture of the brain...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $752,525 to Rutgers, The State University to examine the role of the microtubule network in a mouse model of Alzheimer's disease. The award will study how changes in microtubule stability and the microtubule-binding protein stathmin affect synaptic localization of the GLUA2 subunit, synaptic plasticity, and memory deficits in a tau-related Alzheimer's model. Key objectives include...
This federal Project Grant award, valued at $246,248.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to investigate how disrupted autophagy, a cellular process, contributes to the progression of Alzheimer's disease and related dementias. The research aims to elucidate the molecular mechanisms by which specific...
This $3,967,524 project grant from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research into the vascular contribution to white matter lesions and motor dysfunction in Alzheimer's disease and related dementias. The grantee, Rutgers, The State University of New Jersey, will analyze post-mortem brain tissues from Alzheimer's patients exhibiting early-stage motor deficits. Researchers will investigate pathogenic mechanisms of motor dysfunction in rodent models of...
This federal Project Grant award, with ID R01AG092468, was provided by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The $913,225 award supports research to systematically characterize proteinopathies, such as amyloid-beta, tau, alpha-synuclein, and TDP-43, as well as U1 small nuclear ribonucleoprotein (U1 SNRNP) dysfunction and associated splicing abnormalities in Alzheimer's disease (AD) and AD-related dementias (ADRD). The research, led by...
The National Institute on Aging awarded a $480,536 Project Grant under the Aging Research program (CFDA 93.866) to The Jackson Laboratory to fund research aimed at improving treatment for Alzheimer's disease and related dementias (ADRD). The project will assess whether manipulating the angiopoietin/tie2 (ANG/TIE2) signaling pathway can preserve blood-brain barrier (BBB) integrity and prevent cerebrovascular dysfunction, which are major contributors to many ADRDs. The research approach involves...
This federal Project Grant award, valued at $6,226,692.00 and funded by the National Institute on Aging (CFDA 93.866 - Aging Research), supports research to investigate the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to track early electrophysiological changes in the locus coeruleus (LC) and hippocampus (HPC) as key brain regions impacted by the accumulation of beta-amyloid and tau proteins. The research seeks to understand...
This $3,845,311 federal Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to the University of California, San Diego (UCSD) from August 2024 through April 2029. The grant aims to generate age-equivalent neurons from mild cognitive impairment (MCI) patients to investigate early determinants of Alzheimer's disease (AD). Key goals include: Integrating polygenic risk scores for AD with multi-omic analysis of MCI patient-derived...