This Project Grant award from the National Institutes of Health National Institute of Neurological Disorders and Stroke provides $4,036,400 to Drexel University to support research investigating immune modulating therapies for the treatment of Complex Regional Pain Syndrome (CRPS). The award period is from September 30, 2022 through August 31, 2025. The grant funds research aimed at elucidating mechanisms of T cell dysfunction in CRPS and investigating novel immune modulating therapies. Specifically, the researchers will examine dysregulated circulating microRNA signatures common to both CRPS patients and a mouse tibia fracture model of CRPS that can regulate circulating and tissue-resident memory T cells, which have been implicated in CRPS pathology. The study hypothesizes that pathological circulating and tissue-resident memory T cells converge on targets crucial for their homeostasis and formation, contributing to CRPS. The researchers will test whether these T cell populations contribute to CRPS and if cooperatively targeting them can serve as a novel therapeutic strategy. Overall, the grant supports efforts to better understand immune system mechanisms in CRPS and develop new treatment approaches. The award falls under the National Institutes of Health's Drug Abuse and Addiction Research Programs (CFDA 93.279), which supports neuroscience, biomedical, behavioral and social science research on the prevention, diagnosis, treatment, etiology and health services related to substance abuse and addiction.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.0m | 9/19/22 | ||
| Not listed | $2.0m | 9/19/22 |