Project Grant RF1NS130481

Award Date 9/30/22
Completion Date 8/31/25
Dollars Obligated $4M
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
MIDDLE CITY EAST, PA 19102, USA
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The grant funds research aimed at elucidating mechanisms of T cell dysfunction in CRPS and investigating novel immune modulating therapies. Specifically, the researchers will examine dysregulated circulating microRNA signatures common to both CRPS patients and a mouse tibia fracture model of CRPS that can regulate circulating and tissue-resident memory T cells, which have been implicated in CRPS pathology. The study hypothesizes that pathological circulating and tissue-resident memory T cells converge on targets crucial for their homeostasis and formation, contributing to CRPS. The researchers will test whether these T cell populations contribute to CRPS and if cooperatively targeting them can serve as a novel therapeutic strategy. Overall, the grant supports efforts to better understand immune system mechanisms in CRPS and develop new treatment approaches.

The award falls under the National Institutes of Health's Drug Abuse and Addiction Research Programs (CFDA 93.279), which supports neuroscience, biomedical, behavioral and social science research on the prevention, diagnosis, treatment, etiology and health services related to substance abuse and addiction.

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