Project Grant RF1MH138591
- This $189,540 Project Grant award from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) aims to investigate the role of cortico-striatal circuitry in model-based decision-making, a key process underlying behavioral flexibility. The project will be conducted by the University of Pittsburgh over a 5-year period from February 2025 to January 2030. The research will utilize in vivo electrophysiology and optogenetics to monitor and manipulate neural activity in...
- This federal Project Grant award of $1,987,812 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to identify the computations and neural mechanisms for economic decisions between multiple options using a nonhuman primate model. The key objectives are to: Characterize how neurons in the ventromedial and orbital prefrontal cortex compare decision options and assign subjective values to each option. Determine the causal...
- This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $484,546 to Northwestern University to conduct research on "Transformation of Value in the Basal Ganglia". The project will develop a new foraging task for mice to study how the brain encodes the costs and benefits of decision-making, with a focus on the role of the basal ganglia. The research aims to test a model of how the...
- This federal Project Grant award of $196,460 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), is supporting research to elucidate the neural substrates underlying novelty-related social investigation behaviors in mice. The research aims to leverage in vivo recording techniques, projection-specific optogenetic stimulation, and computational approaches to determine how social recognition information encoded in the ventral...
- This federal Project Grant award of $136,050.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate how a specific protein, BTBD11, regulates the function and composition of glutamatergic synapses in interneurons. The research aims to elucidate the role of BTBD11 and liquid-liquid phase separation in maintaining the unique properties of glutamatergic synapses in interneurons, which are...
- The National Institute of Mental Health (NIMH) awarded a $1,380,070 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Duke University to explore the cellular properties and circuit functional roles of human cortical interneurons. This research aims to generate a multimodal phenotypic catalog of human interneurons and characterize their functional organization in neural circuits. The project will utilize live brain specimens collected from neurosurgical procedures and a novel genetic...
- This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports research on the molecular and functional implications of thalamo-striatal synapse regulation in learning and memory. The $119,742 award, provided to the Regents of the University of Minnesota, aims to investigate the regulatory mechanisms by which thalamo-striatal synapses are preferentially lost in the aging striatum and how this...
- This federal Project Grant award, valued at $216,689.00 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research aimed at measuring the effective connectivity between excitatory and inhibitory neurons in the brain to reveal the underlying connectivity motifs and computations that contribute to decision-making. The research, to be conducted by...
- This federal Project Grant award of $774,632 was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award supports research to understand how changes in dopamine signaling impact neural circuits and contribute to symptoms like impaired cognition and perception in dopamine-associated neuropsychiatric diseases. The key objectives are to use in vivo imaging to determine how selectively activating dopamine neurons in the...
- This three-year project grant from the Department of Health and Human Services National Institutes of Health provides $3,555,862 to The Trustees of the University of Pennsylvania under the Trans-NIH Research Support program (CFDA 93.310) to study the interactions between the locus coeruleus-norepinephrine system and the dorsolateral prefrontal cortex in flexible decision-making. Specifically, the researchers will train monkeys on a novel task to quantify how learned expectations and new...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,693,038 to The Trustees of the University of Pennsylvania to examine the role of striatal interneurons in value-based decision making. The 4-year project aims to systematically investigate how two specific striatal interneuron subtypes, low threshold spiking interneurons (LTSIs) and tyrosine hydroxylase-positive interneurons (THINs), contribute to distinct components of value-based behavioral control. Using a modular, head-fixed choice task combined with viral-genetic tools, the research seeks to advance the understanding of how local striatal circuits filter and amplify behaviorally relevant inputs to shape motor output. The findings could provide insights into the neural mechanisms underlying impairments in goal-directed decision making observed in various mental health disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.7m | 8/20/25 |