This Project Grant award of $324,464 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to characterize the early childhood neurodevelopmental impacts of infants exposed to maternal SARS-CoV-2 infection during pregnancy. The grantee, Ann & Robert H Lurie Children's Hospital of Chicago, will utilize their longitudinal SNIPP cohort of approximately 4,000 mother-infant pairs affected by SARS-CoV-2 infection during...
The National Institute of Mental Health (NIMH) awarded a $245,475 Project Grant (CFDA 93.242 - Mental Health Research Grants) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on defining the neuro-immune and placental profile of a dual-hit Toll-Like Receptor 7 (TLR7) and stressor mouse model. The key objectives of this 2-year research project are to determine whether prenatal TLR7 stimulation induces maternal, placental, and...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $183,096 to the University of Maryland, Baltimore to study the structural, functional, and neurobehavioral consequences of COVID-19 infection in adolescents. The key products and services to be delivered include: Longitudinal neuroimaging, cognitive, and psychiatric symptom data analysis to identify brain morphometric, microstructural, and functional...
This $664,837 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to comprehensively screen newborns for in-utero SARS-CoV-2 infection and assess associated immune responses and clinical outcomes. The primary objectives are to: 1) Identify newborns with in-utero SARS-CoV-2 infection using a multi-faceted approach involving antibody and PCR testing of cord blood, placental...
This $6,439,263 federal Project Grant awarded by the National Institute on Drug Abuse (CFDA 93.279 Drug Abuse and Addiction Research Programs) aims to determine the impact of maternal substance use on maternal immune activation, placental function, and offspring neurobehavioral development. The project will leverage the Healthy Brain and Child Development (HBCD) study to perform maternal immune profiling, placental and cord blood analysis, and novel neuroinflammation imaging on 400 pregnancies...
This three-year, $3.456 million project grant from the National Institute of Mental Health (NIMH) Mental Health Research Grants program (CFDA 93.242) will fund research into the role of microglia in neurodevelopmental disorders. The grantee, Cold Spring Harbor Laboratory, will merge two-photon imaging of microglia and synapses in the brains of live mice with single-cell genomics and CRISPR screens. This will help define microglia's role in experience-dependent synaptic refinement, a process...
This federal Project Grant award of $418,178 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to provide mechanistic insights into the neurobiological mechanisms by which maternal sensitivity is compromised by postpartum depression. Specifically, the University of Massachusetts (UMass), through its Office of Grant & Contract Administration, will use intersectional viral...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $240,000 to the University of Texas Medical Branch at Galveston (UTMB) to develop a hamster model to study the neurological and behavioral impacts on offspring from mothers infected with SARS-CoV-2. The goal is to better understand the potential long-term societal effects...
This Project Grant award of $600,000 from the National Institutes of Health's Trans-NIH Research Support program (CFDA 93.310) supports research to elucidate the role of antibodies in the neurological effects of COVID-19, known as "NeuroCOVID-19". The overarching goal is to investigate how inflammatory immunoglobulin G (IgG) antibodies associated with SARS-CoV-2 infection may trigger activation and damage to brain cells and endothelial cells, leading to disruptions in brain...
This federal Project Grant award of $3,155,102 from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) aims to assemble a large global consortium to evaluate the social determinants of mental health outcomes related to the COVID-19 pandemic. The project, titled "International Evaluation of Modifiable Social Determinants of Health on COVID-Related Mental Health Outcomes," will integrate longitudinal data from 23 international cohorts comprising...
This $5.1 million project grant from the National Institute of Mental Health (NIMH), part of the Department of Health and Human Services, supports research under the Mental Health Research Grants program (CFDA 93.242).
The Massachusetts General Hospital will utilize its existing biobank of over 800 maternal blood and neonatal cord blood samples linked to clinical records to characterize the impact of maternal SARS-CoV-2 infection on fetal neurodevelopment. Researchers will analyze immune responses in maternal blood and create personalized models of microglial cell function from cord blood to compare inflammatory phenotypes between exposed and unexposed neonates. In parallel, they will examine risk for neurodevelopmental diagnoses in over 10,000 deliveries to assess potential long-term effects.
Additionally, $121,810 in subawards to Harvard University will support immune analyses of maternal peripheral blood mononuclear cells and plasma to quantify cytokine responses under the direction of co-investigator Dr. Huh and his postdoctoral fellow. Findings from this research may help identify biomarkers of risk and potential interventions to minimize adverse neurodevelopmental outcomes in offspring exposed to SARS-CoV-2 in utero.