243744S
NESTED IN A PREEXISTING COLLABORATION BETWEEN LEADING RESEARCH GROUPS IN MENTAL HEALTH ACROSS FOUR NORDIC COUNTRIES (ICELAND, SWEDEN, NORWAY AND DENMARK) AND OTHER INTERNATIONAL PARTNERS (ESTONIA AND THE UK), THE COVIDMENT CONSORTIUM HAS DEVELOPED A UNIQUE RESEARCH INFRASTRUCTURE TO ADDRESS QUESTIONS ON THE MENTAL HEALTH IMPACT OF COVID-19. THESE INCLUDE NATIONAL REGISTRY RESOURCES OF EST. >22 MILLION INDIVIDUALS (OF WHICH >7.2 MILLION HAVE CONFIRMED COVID-19 INFECTION) AND SEVERAL COVID-19 COHORTS WITH HARMONIZED QUESTIONNAIRE DATA COLLECTIONS FROM CA. 550.000 INDIVIDUALS. USING THESE RESOURCES, THE COVIDMENT CONSORTIUM HAS GENERATED IMPORTANT KNOWLEDGE THROUGH META-ANALYSES OF DATA ACROSS THE PARTICIPATING COUNTRIES/COHORTS, E.G. RESULTING IN IMPORTANT INSIGHTS ON THE TEMPORAL ASSOCIATION BETWEEN NATIONAL COVID-19 INCIDENCE AND DEPRESSIVE SYMPTOMS IN THE GENERAL POPULATION (UNNARSDóTTIR ET AL., IJE 2021) AS WELL AS THE ROLE OF ACUTE COVID-19 ILLNESS SEVERITY IN LONG-TERM MENTAL HEALTH SYMPTOMS AMONG RECOVERING PATIENTS (MAGNúSDóTTIR ET AL., LANCET PUBLIC HEALTH, 2022). NOW EXTENDING THE RESEARCH PROGRAM TO A GLOBAL COLLABORATION, THE COVIDMENT CONSORTIUM WILL, AS BEFORE, BE LED BY PROF. VALDIMARSDóTTIR WHO WILL TOGETHER WITH PROF. ANDREASSEN AND OTHER COVIDMENT PIS CONTINUE TO CONDUCT HARMONIZED DATA COLLECTIONS ACROSS COHORTS/COUNTRIES AND CONTRIBUTE DATA TO THE SPECIFIC AIMS OF THIS PROGRAM. THIS ENTAILS WORKING CLOSELY WITH THE PIS (PROF. SMOLLER, DR. BAUERMEISTER AND PROF. BRUNONI) TO CONSTRUCT AND IMPLEMENT STATISTICAL ANALYTIC PLANS WITHIN EACH COHORT ADDRESSING THE SPECIFIED RESEARCH QUESTIONS AND DELIVER AGGREGATE DATA THAT CAN BE META-ANALYZED WITHIN THIS PROGRAM. COVIDMENT RESEARCHERS WILL FURTHER CONTRIBUTE TO THE INTERPRETATION OF DATA, WRITING AND PUBLICATIONS OF THE STUDY FINDINGS.
University Of Iceland
Project Grant RF1MH134638
$39.0k 9/27/24 243744S
BACKGROUND THE COVID-19 PANDEMIC HAS PRESENTED VARIOUS PSYCHOLOGICAL CHALLENGES, SUCH AS UNCERTAINTY AND FEAR ABOUT THE VIRUS, ENFORCED SOCIAL ISOLATION CAUSED BY LOCKDOWN AND SOCIAL DISTANCING MEASURES, FINANCIAL ADVERSITIES, REDUCED ACCESS TO HEALTHCARE SERVICES AND SO FORTH. THERE IS COMPELLING EVIDENCE SHOWING WORSENING MENTAL HEALTH DURING, COMPARED TO PRIOR TO, THE PANDEMIC. EXISTING RESEARCH HAS SHOWN THAT PEOPLE WITH CERTAIN SOCIO-DEMOGRAPHIC CHARACTERISTICS (E.G. YOUNGER PEOPLE, FEMALE, ETHNIC MINORITIES) ARE WORSE AFFECTED. HOWEVER, THERE IS STILL A LACK OF RESEARCH ON MODIFIABLE SOCIAL DETERMINANTS OF MENTAL HEALTH OUTCOMES. FURTHER, THERE IS A LOT OF VARIATION IN COVID-19 INTENSITY AND POLICY RESPONSES ACROSS COUNTRIES (AND OVER TIME), IN ADDITION TO DIFFERENCES IN SOCIAL NORMS, POLITICAL AND ECONOMIC FACTORS. THEREFORE, IT IS IMPORTANT TO CONDUCT CROSS-COUNTRY COMPARISONS WHEN EVALUATION THE MENTAL HEALTH IMPLICATIONS OF THE COVID-19 PANDEMIC AND THE ASSOCIATED MODIFIABLE SOCIAL DETERMINANTS. B. OBJECTIVES THE OBJECTIVE OF THIS APPLICATION IS TO SUPPORT THE OVERALL PROJECT LED BY PROF JORDAN SMOLLER BY PROVIDING VALIDATION ANALYSES USING LONGITUDINAL DATA FROM THE UNITED KINGDOM (UK). C. TASKS AS THE SUBAWARD SITE, WE WILL CONDUCT VALIDATION ANALYSES USING DATA FROM THE COVID-19 SOCIAL STUDY, A LARGE PANEL SURVEY OF OVER 72,000 PARTICIPANTS LIVING IN THE UK. THE DATA CONTAIN OVER 1.2 MILLION RECORDS, COLLECTED OVER 41 WAVES BETWEEN MARCH 2020 TO APRIL 2022. THE DATA ANALYSES WILL BE CONDUCTED BY DR FEIFEI BU WHO IS THE SENIOR STATISTICIAN OF THE COVID-19 SOCIAL STUDY. DR BU WILL ALSO BE RESPONSIBLE FOR THE OVERALL COORDINATION WITH THE LEAD ORGANIZATION AND OTHER RESEARCH TEAMS. THE PROJECT WILL BE OVERSEEN BY DR DAISY FANCOURT WHO IS THE PRINCIPLE-INVESTIGATOR OF THE COVID-19 SOCIAL STUDY. BOTH DR BU AND DR FANCOURT WILL CONTRIBUTE TO REPORTING AND DISSEMINATING RESEARCH FINDINGS (E.G. PROJECT MEETINGS, PROGRESS REPORTS, ACADEMIC PUBLICATIONS, CONFERENCES ETC.).
University College London
Project Grant RF1MH134638
$39.0k 9/27/24 243744S
THE CANADIAN PARTNERSHIP FOR TOMORROWÂ S HEALTH (CANPATH) IS PLEASED TO JOIN THIS INITIATIVE TO STUDY MODIFIABLE SOCIAL DETERMINANTS OF HEALTH ON COVID-19 RELATED MENTAL HEALTH OUTCOMES WITH 30 COHORTS AND PRE- AND POST-PANDEMIC DATA FROM MORE THAN TWO MILLION PARTICIPANTS. THE PROPOSED PROJECT BUILDS ON A SUCCESSFUL THREE SITE PILOT STUDY SUPPORTED AND FUNDED BY THE INTERNATIONAL HUNDRED THOUSAND COHORT CONSORTIUM, WELLCOME TRUST, AND THE NATIONAL INSTITUTES OF HEALTH. THE PROPOSED ACTIVITIES RECOGNIZE THE IMPACT OF THE COVID-19 PANDEMIC ON MENTAL HEALTH PROVINCIALLY, NATIONALLY, AND GLOBALLY AND, AS SUCH, ARE ALIGNED WITH THE MISSION OF CANPATH. A MEMBER OF THE INTERNATIONAL HUNDRED THOUSAND COHORT CONSORTIUM, CANPATH IS THE LARGEST LONGITUDINAL COHORT STUDY IN CANADA, WITH MORE THAN 330,000 PARTICIPANTS AGED 30-74 IN REGIONAL COHORTS ACROSS THE COUNTRY. CANPATH IS A CRITICAL COMPONENT IN CANADAÂ S STRONG RESEARCH ENVIRONMENT AND HAS PRODUCED BOTH NATIONALLY AND INTERNATIONALLY RECOGNIZED FINDINGS. CANPATH HAS UNDERTAKEN VITAL WORK TO BETTER UNDERSTAND HOW FACTORS SUCH AS INDIVIDUAL LIFESTYLE, BEHAVIOUR, GENETICS, AND THE ENVIRONMENT INTERACT AND LEAD TO CANCER AND OTHER CHRONIC DISEASE. THE NATIONAL COHORT BRINGS TOGETHER SIX CANADIAN REGIONAL COHORTS REPRESENTING NINE PROVINCES, INCLUDING BC GENERATIONS PROJECT, ALBERTA'S TOMORROW PROJECT, MANITOBA FOR TOMORROW PROJECT, ONTARIO HEALTH STUDY, CARTAGENE (QUEBEC), AND ATLANTIC PATH. THE LONGITUDINAL NATURE OF THE COHORT ALLOWS US TO FOLLOW PARTICIPANTS AND CAPTURE CHANGES IN THEIR HEALTH OUTCOMES AS THEY AGE AND, RESULTANTLY, IDENTIFY NOVEL RISK FACTORS FOR DISEASE. IMPORTANTLY, ALL PARTICIPANTS HAVE CONSENTED TO THE USE OF THEIR DATA IN HEALTH RESEARCH STUDIES. THE COVID-19 PANDEMIC HAS BROUGHT AN UNPRECEDENTED SET OF CHALLENGES IMPACTING GLOBAL MENTAL HEALTH. THE SCALE OF THE PROPOSED RESEARCH IS UNPRECEDENTED IN THIS AREA AND WILL INFORM ONGOING PANDEMIC MANAGEMENT OF MENTAL HEALTH. CANPATHÂ S RELEVANT SELF-REPORTED DATA HOLDINGS INCLUDE: Â ¢ 330,000 PARTICIPANTS AT BASELINE (2009-2016) O SELF-RATED HEALTH SCALE O SUBSET OF REGIONAL MENTAL HEALTH DATA (GAD-7 AND PHQ-9) Â ¢ 134,421 PARTICIPANTS AT FIRST FOLLOW-UP PERIOD (2016-2018) O GAD-7 AND PHQ-9 O DIAGNOSIS OF MENTAL HEALTH CONDITION O SELF-RATED HEALTH SCALE Â ¢ 97,757 PARTICIPANTS AT COVID-19 TIMEPOINT ONE (2020) O GAD-7 AND PHQ-8 O DIAGNOSIS OF MENTAL HEALTH CONDITION O SAME DATA FOR A SMALLER SUBSET OF PARTICIPANTS AT MULTIPLE TIME POINTS FROM A CANPATH COVID-19 SEROLOGY STUDY (2021-2022) THE OVERARCHING AIMS FOR THE PROPOSED PROJECT INCLUDE: 1) ASSEMBLING LONGITUDINAL DATA ACROSS GLOBAL COHORTS, HARMONIZING DATA FOR DOWNSTREAM ANALYSES AND DEVELOPING A DATA VISUALIZATION PLATFORM FOR THE SCIENTIFIC COMMUNITY; 2) IDENTIFYING MODIFIABLE RISK AND PROTECTIVE FACTORS FOR PANDEMIC-RELATED MENTAL HEALTH OUTCOMES (E.G., ANXIETY, DEPRESSION, SUBSTANCE USE, AND SUICIDALITY) WHILE CONSIDERING INDIVIDUAL-LEVEL AND STRUCTURAL FACTORS, AS WELL AS THEIR JOINT EFFECTS; AND 3) ESTABLISHING AND FORMALIZING THE COVID GLOBAL MENTAL HEALTH CONSORTIUM FOR FUTURE, ONGOING RESEARCH ON THE IMPACT OF THE COVID-19 PANDEMIC ON GLOBAL MENTAL HEALTH. DR. ROBIN URQUHART IS THE SCIENTIFIC DIRECTOR OF ATLANTIC PATH, AND CANADIAN CANCER SOCIETY ENDOWED CHAIR IN POPULATION CANCER RESEARCH AT DALHOUSIE UNIVERSITY AND WILL REPRESENT CANPATH AS THE NOMINATED PRINCIPAL INVESTIGATOR IN THIS WORK. DR. URQUHART WILL CONTRIBUTE HER EXPERTISE IN CANCER AND POPULATION HEALTH AND ENGAGE WITH THE RESEARCH LEADS AND THE ATLANTIC PATH AND CANPATH TEAM MEMBERS FOR THE DURATION OF THE PROJECT (2023-2026). CANPATH HAS AN ESTABLISHED MENTAL HEALTH RESEARCH STREAM LED BY DR. ELLEN SWEENEY (RESEARCH DIRECTOR, ATLANTIC PATH, DALHOUSIE UNIVERSITY). DR. SWEENEY WILL BE RESPONSIBLE FOR THE OVERALL COORDINATION AND SUPERVISION OF THE STUDY WHILE REPRESENTING CANPATH, INCLUDING DATA MANAGEMENT AND AS THE PRIMARY POINT OF COMMUNICATION. IN YEAR ONE, SHE WILL SUPPORT AND FACILITATE THE CANPATH DATA ACCESS PROCESS. SHE WILL WRITE AND SUBMIT AN REB APPLICATION AT DALHOUSIE UNIVERSITY TO COVER THE OVERARCHING PROJECT AND SPECIFICALLY FOR THE INITIAL DATA ANALYSIS COMPONENT TO OCCUR IN-HOUSE AT ATLANTIC PATH. SHE WILL FACILITATE ANY RELEVANT INSTITUTIONAL AGREEMENTS REQUIRED FOR DATA TO BE TRANSFERRED FROM CANPATH TO ATLANTIC PATH, AND AGGREGATE DATA FROM ATLANTIC PATH TO THE MASSACHUSETTS GENERAL HOSPITAL. IN YEARS ONE AND TWO, DR. SWEENEY WILL WORK WITH HER COLLEAGUE, MR. YUNSONG CUI DURING THE DATA ANALYSIS STAGE OF THE PROJECT. IN YEARS ONE AND TWO, MR. CUI (DATA ANALYST, ATLANTIC PATH) WILL BE RESPONSIBLE FOR THE STANDARDIZATION AND HARMONIZATION OF RELEVANT CANPATH VARIABLES IN PREPARATION FOR ANALYSES IN COLLABORATION WITH THE RESEARCH LEADS AND TEAM. HE WILL CONDUCT THE FEDERATED ANALYSES OF ALL CANPATH DATA. AGGREGATE DATA PRODUCED FROM THESE ANALYSES WILL BE TRANSFERRED TO THE RESEARCH LEAD WITH THE ASSISTANCE OF THE ATLANTIC PATH DATA MANAGER. MR. CUI HAS EXTENSIVE EXPERTISE IN HEALTH RESEARCH AND STATISTICAL ANALYSIS, AS WELL AS EXPERIENCE CONDUCTING ANALYSES FOR A PROJECT LED OUT OF THE NETHERLANDS THAT HAS A SIMILAR METHODOLOGY (E.G., FEDERATED ANALYSES AND THEN A META-ANALYSIS OF MULTIPLE COHORTSÂ AGGREGATE DATA IN A CENTRALIZED LOCATION). WHILE THIS WORK WILL BE LED BY A REGIONAL COHORT AT ATLANTIC PATH, DR. PHILIP AWADALLA (SCIENTIFIC DIRECTOR, CANPATH) WILL REPRESENT CANPATH AND THE NATIONAL COORDINATING CENTRE AT THE UNIVERSITY IN TORONTO. THE ATLANTIC PATH TEAM MEMBERS WILL BE IN REGULAR COMMUNICATION WITH DR. AWADALLA FOR THE DURATION OF THE PROJECT. DR. URQUHART, DR. SWEENEY, DR. AWADALLA, AND MR. CUI WILL ALL BE AVAILABLE TO PARTICIPATE IN ACTIVITIES LED BY THE LEAD RESEARCHER AND TEAM THROUGHOUT THE PROJECT, INCLUDING BUT NOT LIMITED TO DISCUSSION OF THE VARIABLES AND FINDINGS IN AIM TWO, CONTRIBUTING TO MANUSCRIPT PREPARATION AND REVIEW, AND KNOWLEDGE TRANSLATION ACTIVITIES WHICH WILL BENEFIT FROM LEVERAGING OUR EXISTING INFRASTRUCTURE AND REGIONAL AND NATIONAL CONTACTS. WE EXPECT CANPATH TO JOIN THE COVID GLOBAL MENTAL HEALTH CONSORTIUM AS A FORMAL MEMBER AND TO ATTEND BIANNUAL MEETINGS DURING THE PROJECT AND MOVING FORWARD, AS WELL AS CONTRIBUTING TO THE PLATFORM FOR ONGOING COLLABORATIVE RESEARCH EFFORTS RELATED TO GLOBAL MENTAL HEALTH AND THE COVID-19 PANDEMIC. WE LOOK FORWARD TO JOINING THE CONSORTIUM AND CONTRIBUTING TO THIS IMPORTANT WORK. SUCCESSFUL COMPLETION OF THIS RESEARCH WILL PROVIDE THE LARGEST GLOBAL COHORT RESOURCE FOR THE INVESTIGATION OF COVID-RELATED MENTAL HEALTH OUTCOMES, MAJOR ADVANCEMENT INTO THE UNDERSTANDING OF INDIVIDUAL MENTAL HEALTH RISK TRAJECTORIES DURING THE PANDEMIC, AND THE MOST IN-DEPTH UNDERSTANDING OF KEY GLOBAL PANDEMIC MANAGEMENT OF MENTAL HEALTH-RELATED FACTORS.
Dalhousie University
Project Grant RF1MH134638
$43.9k 9/27/24