This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research to develop a novel golden Syrian hamster model to examine the neurological and behavioral impacts on offspring from mothers infected with SARS-CoV-2. The $240,000 award, with a period of performance from December 15, 2024 to November 30, 2026, will support two key research aims. The first aim will focus on directly studying the effects of maternal SARS-CoV-2 infection on the female reproductive tract, developing fetus, and placenta, including identifying any vertical transmission and inflammatory responses. The second aim will explore the long-term behavioral and neurological implications for the resulting offspring, utilizing optimized tests for depression, muscle weakness, and cognition/memory. Extensive histopathological analysis, neuroimaging, and molecular biology techniques will also be employed to assess the impact of maternal infection. This research is intended to help prepare public health entities for the potential long-term societal impacts of COVID-19 maternal infection and provide a valuable model system for further mechanistic and interventional studies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $240.0k | 12/11/24 |