This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is funding a $682,470 research project at the University of California, Los Angeles (UCLA) to elucidate the mechanisms of cortical arealization and laminar identity during human brain development. The goal is to identify novel transcriptional regulators of cell fate specification in the developing human cortex, which could improve understanding of the...
The National Institute of Mental Health (NIMH) awarded a $1,244,076 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Spatial Genomics, Inc. to develop next-generation spatial genomics tools for visualizing gene expression in human brain tissues. The goal is to scale up the multiplexity of assays available on Spatial Genomics' proprietary GenePS platform, which uses sequential fluorescence in situ hybridization (seqFISH) technology to image up to 10,000 genes directly in tissue...
This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
The Scripps Research Institute was awarded a $4.6 million project grant from the National Institute of Mental Health to develop novel tools for molecular profiling of brain cell types. The grant is part of NIMH's Mental Health Research Grants program (CFDA 93.242), which supports basic and clinical research to transform the understanding and treatment of mental illnesses. Under the award, Scripps will expand its RIBO-STAMP technology to enable comprehensive measurement of translational...
The National Institute of Mental Health (NIMH) awarded a 5-year, $11,731,574 Cooperative Agreement to the Massachusetts Institute of Technology (MIT) under the Mental Health Research Grants program (CFDA 93.242). The grant's objective is to create comprehensive 3D atlases of the human and non-human primate brain, capturing detailed functional, structural, and multi-omic data. Using state-of-the-art imaging technologies, the project will map brain-wide function, structure, and high-dimensional...
The National Institute of Mental Health (NIMH) awarded a $2,490,741 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College (Harvard University) to develop the THERMAL-PLEX method. This fluidic-free, rapid sequential imaging technique enables multiplexed analysis of RNA and protein in brain tissues, providing critical insights into the spatial organization of molecular targets. The 3-year project aims to remove complex and slow...
This $21.4 million cooperative agreement from the National Institute of Mental Health will fund research to identify gene regulatory elements that can target and manipulate specific neuronal cell types and brain circuits across species, including in human organoids. Awarded on September 1, 2022 to the Broad Institute, Inc. with completion by August 31, 2025, the funding supports the Mental Health Research Grants program. The Broad Institute and collaborators at Harvard University will profile...
The National Institute of Mental Health awarded Oregon Health & Science University a $4,214,208 project grant under the Mental Health Research Grants program (CFDA 93.242) for the period of August 1, 2022 through July 31, 2025. The grant funds development of a new technique called SLIDE-SBARRO to generate quantitative models of synaptic networks in mouse striatum through spatially-resolved single-cell RNA sequencing of hundreds of thousands of cells. The aims are to create an...
The National Institute of Mental Health (NIMH) awarded a $782,271 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to the University of California, Los Angeles (UCLA) to advance precision psychiatry research. The 5-year project, titled "PSYCHEMERGE: ADVANCING PRECISION PSYCHIATRY", aims to: Create a nationwide federated transfer-learning platform for developing generalizable and bias-aware algorithms. Integrate state-of-the-art methods to perform inclusive...
This $3,498,931 Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports a comprehensive research initiative titled "Cross Scale Interrogation of NPD Genes (SING) in Mice". The primary objective is to investigate the impact of the loss of 100 neurodevelopmental and psychiatric disorder (NPD) genes in mice across multiple scales, including gene expression, cellular changes, neural circuit...