This $2,576,654 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support the development of a cloud-based software platform and advanced computational pipelines to harmonize and integrate spatial transcriptomics data for the construction of a spatially resolved brain atlas. Key objectives of the 3-year project include: 1) Creating a cloud-based platform to standardize the analysis and visualization of...
The Project Grant award R43MH135772, totaling $300,691.00, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The award aims to advance Numentus Technologies Inc.'s high-speed hyperspectral imaging technology for highly multiplexed immunofluorescence imaging in pathology. The project will improve the company's technology to enable rapid, cost-effective detection of up to 12 molecular targets in a single tissue sample,...
The National Institute of Mental Health (NIMH) awarded a $314,113 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Physical Sciences Inc. (PSI), a for-profit R&D company in Andover, MA. The project aims to develop and demonstrate a high-speed (>140 Hz frame rate) multicolor confocal fluorescence imager that can simultaneously capture multi-wavelength signals and display them as separated or merged multicolor images and 3-D stacks. This technology will be used to map...
The National Institute of Mental Health awarded a three-year Project Grant totaling $3,618,976 to the University of California, Los Angeles under the Mental Health Research Grants program (CFDA 93.242) to develop in situ single-cell multi-omic and morphological profiling methods for mammalian brains. Specifically, the university will work to design photonic-indexing sequencing strategies to spatially barcode tissue with single-cell resolution, integrating techniques such as PI-ATAC-seq and...
The National Institute of Mental Health (NIMH) awarded a $505,311 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to Intelligent Imaging Innovations, Inc. (3i) to develop a commercial instrument for large-scale, all-optical electrophysiology. The project aims to combine advanced optical techniques, including volumetric neural activity imaging and computer-generated holography, to enable simultaneous optical recording and manipulation of neuron activity across multiple...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $457,026 to Magnify Biosciences Inc. to develop a prototype of the Multiplex Magnify sample preparation kits for high-plex, super-resolution 3D synaptic imaging and analysis in neuroscience research. The key products and services to be delivered include: (1) validating Magnify-compatible antibodies and a novel direct immunostaining strategy for key...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $2,415,243 to The Broad Institute, Inc. to develop a scalable, cloud-based framework for multi-modal mapping across single neuron omics, morphology, and electrophysiology. The framework aims to enable integrative, data-driven characterization of brain cell types, leveraging federated Brain Initiative resources and community engagement....
The National Institute of Mental Health (NIMH) awarded a $299,896 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to In Vivo Analytics, Inc., a for-profit corporation, to develop a modular bioluminescence imaging platform. The platform aims to address key challenges in preclinical bioluminescence imaging, including limited photon detection, single-view limitations, and complexities in quantitative analysis. The project focuses on enhancing imaging sensitivity,...
The National Institute of Mental Health (NIMH) awarded a $2,490,741 Project Grant under the Mental Health Research Grants program (CFDA 93.242) to President and Fellows of Harvard College (Harvard University) to develop the THERMAL-PLEX method. This fluidic-free, rapid sequential imaging technique enables multiplexed analysis of RNA and protein in brain tissues, providing critical insights into the spatial organization of molecular targets. The 3-year project aims to remove complex and slow...
This Project Grant award, totaling $800,485, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) to investigate the role of human-specific 3D genome conformation in brain development and disease. The project aims to analyze genome conformation in human and primate cortical neuroprogenitor cells and neurons to identify human-specific topologically associated domains (TADs), predict their functionality, and validate their...