This federal Project Grant award by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) is designed to enhance the delivery of non-viral, neuron-specific molecules across species in the central nervous system. The $821,998 award to the University of Texas at Dallas will fund a comprehensive effort to characterize the neuron-targeting capabilities of a novel 15-amino acid peptide, N1, and optimize its stability and delivery, including...
This $1,526,424 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research at the University of Texas Southwestern Medical Center to investigate the impact of DNA supercoiling and topoisomerases on neuronal activity-dependent chromatin organization. The research will map the distribution of underwound (negatively supercoiled) DNA and the genome-wide sites of catalytically engaged topoisomerases in...
This $1,242,117 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports the development of novel Cre-dependent adeno-associated viruses (AAVs) with minimal off-target expression. The goal is to create improved tools for studying neural circuits, including markers, optogenetic/chemogenetic actuators, and biosensors. The research aims to address issues with current Cre-dependent AAV designs, which can exhibit...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, provides $600,000.00 to The University of Texas Southwestern Medical Center in Dallas, TX. The funding will be used to purchase a TissueVision TissueCyte 1600FC Serial Two-Photon Tomography (STPT) microscope. This advanced imaging system will enable high-throughput, high-resolution automated scanning of whole, uncleared rodent brains and spinal cord...
This $7.6 million project grant from the National Institute of Mental Health, part of the Department of Health and Human Services, will fund research under the Mental Health Research Grants program (CFDA 93.242). Baylor College of Medicine will lead simultaneous high-throughput functional, transcriptomic, and connectivity profiling of neurons in the mouse visual cortex. The research aims to characterize the complex functional properties of neurons using in vivo two-photon imaging combined with...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), supports the development of novel methods for anterograde transsynaptic tracing from genetically-defined excitatory and inhibitory neurons. The $749,331 award, spanning April 2025 to February 2030, will enable the creation of activity-dependent, non-toxic tracing techniques to map neural circuits involved in learning, development, aging, and disease...
This $466,757 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program will support research by the University of Texas at Austin to investigate synaptic plasticity mechanisms that underlie learning and memory formation. The research aims to determine how the structure and dynamics of synaptic active zones and nascent zones contribute to the saturation, recovery, and enhancement of long-term potentiation and depression....
This Project Grant award in the amount of $246,000.00 was provided by the National Institute of Mental Health (NIMH) under the Federal Grant Program "Mental Health Research Grants" (CFDA 93.242). The funding supports research conducted by The University of Texas Southwestern Medical Center (UT Southwestern) aimed at deciphering age-dependent hippocampal hyperactivity and its implications for psychogenesis. The research project utilizes chemogenetic techniques to gradually inhibit...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $2,587,351.00 to the University of Texas Medical Branch at Galveston (UTMB) to conduct research on "Targeting Cell-to-Cell Communication to Prevent Bystander Damage Mediated by Viral Reservoirs." The research will focus on understanding how latent HIV infection in astrocytes in the central nervous system can lead to chronic inflammation and...
This $1,865,347 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support a 5-year research project at the University of Colorado. The project aims to determine how the molecular heterogeneity of ventral tegmental area (VTA) dopamine neurons contributes to associative learning and motivated behaviors. Specifically, the researchers will investigate the neuronal activity patterns and causal roles of VTA...