Project Grant RF1AG098531
- The National Institute on Aging awarded Rosalind Franklin University of Medicine & Science $696,253 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how hormonal fluctuations during perimenopause alter hippocampal neural circuits and accelerate Alzheimer's disease pathology in female mice. The recipient will use 4-vinylcyclohexene diepoxide (VCD) to chemically induce ovarian failure in AppNLGF knock-in AD model mice, mimicking human perimenopause...
- The National Institute on Aging awarded The Washington University $326,550 on June 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the neural circuit basis of age-related changes in female sexual behavior during reproductive aging. The project, led through Washington University's Office of Sponsored Research Services in St. Louis, Missouri, will define how hormonal decline during menopause disrupts hormone-sensitive neural circuits and impairs female sexual behavior....
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $552,154 on February 1, 2026, under the Aging Research program (CFDA 93.866) to characterize hormone therapy use patterns in women with premature or early menopause, identify patient and physician factors associated with therapy initiation and continuation, and develop a dynamic risk prediction model to identify women at high risk for underuse. The project addresses an evidence gap: up to 3.1...
- The National Institute on Aging awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $3,558,232 under the Aging Research program (CFDA 93.866) on August 5, 2026, to conduct the WHIMSY-AD Study examining menopause and related midlife risk factors and their impact on later-life Alzheimer's disease pathology and cognition. The study recontacts 700 participants from the Women's Health Initiative Memory Study of Younger Women (WHIMSY), now aged 75–84 years,...
- The National Institute on Aging awarded Emory University $782,500 under the Aging Research program (CFDA 93.866) on February 1, 2026, to examine how reproductive events influence biological aging processes and menopause timing among Latina women. The award funds analysis of reproductive events—including puberty, pregnancy, and menopause—and their associations with epigenetic aging and menopause in a sample of pre-menopausal Latina women participating in the Hispanic Community Health...
- The National Institute on Aging awarded the University of Delaware $1,303,632 on February 1, 2026, under the Aging Research program (CFDA 93.866) to examine sympathetic nervous system activation during the menopausal transition and its contribution to cardiovascular disease risk in women. The research addresses a gap in understanding physiological changes in cardiovascular function as follicle-stimulating hormone increases and estradiol declines across premenopausal, early perimenopausal, late...
- The National Institute on Aging awarded the University of Southern California $5.945 million on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct the Alzheimer's Risk Intervention Trial with Estradiol (ARITE), a randomized, double-blinded, placebo-controlled investigation of menopausal hormone therapy effects on neuroimaging markers of Alzheimer's disease and related dementias risk in postmenopausal women. The trial enrolls 360 postmenopausal women and uses brain...
- The National Institute on Aging awarded The Regents of the University of Colorado, doing business as University of Colorado-Denver, $189,963 on July 1, 2026, under the Aging Research program (CFDA 93.866) to support research led by Dr. Carlisle investigating the contributions of biological sex and sex hormones to cognitive reserve across the cognitive spectrum of Alzheimer's disease. The research will assess how estrogen and sex differences affect Alzheimer's disease risk, with particular...
- The National Institute on Aging awarded New York University $724,813 under the Aging Research program (CFDA 93.866) effective January 1, 2026, to investigate the association between midlife circulating autoantibodies and Alzheimer's disease risk in women. The recipient, doing business as New York University School of Medicine, will conduct a prospective study examining how autoimmune components relate to AD susceptibility in women, who account for nearly two-thirds of Americans age 65 and...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
The National Institute on Aging awarded New York University School of Medicine $3,557,115 on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate the neurobiological mechanisms linking menopause and cognitive decline in women. The recipient will conduct a longitudinal study mapping neurobiological changes during the menopause transition in a cohort of 120 pre- and perimenopausal women aged 40–48 using state-of-the-art neuroimaging, plasma proteomics, and clinical assessments. The work will elucidate sex-specific neurobiological mechanisms of estrogen loss, quantify the impact of menopausal hormone therapy on brain health, define individual risk profiles for cognitive decline, and identify actionable biomarkers for preventing late-life brain aging. The project addresses a critical gap: women face a 48 percent lifetime risk of developing dementia compared to men, yet current Alzheimer's disease prediction models remain predominantly sex-neutral and fail to account for reproductive history, hormonal changes, and endocrine interventions. Performance occurs at New York University School of Medicine in New York, New York. The period of performance runs from August 5, 2026, through July 31, 2030. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.6m | 8/3/26 |