Project Grant RF1AG095159
- This Project Grant award of $1,602,696 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate the relationship between obesity, cognitive impairment, and neurological disorders such as Alzheimer's disease. The research aims to use magnetic resonance imaging (MRI) techniques to assess neurovascular and lymphatic changes, neuroinflammation, and blood-brain barrier dysfunction in mouse models of obesity-linked cognitive decline. The goal is to identify...
- This federal Project Grant award of $286,000 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), aims to investigate how age-related lipid dysregulation in brain endothelial cells contributes to cognitive impairment. The research will assess the effects of lipid droplet accumulation on endothelial structure and function, and evaluate how this impacts microvascular aging and cognitive decline. The award was made to the University of Oklahoma Health Sciences...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $156,512 project grant to the Regents of the University of Minnesota, to be completed by September 29, 2025. The grant will support research investigating the role of lipid aldehydes in inducing cellular senescence in adipose tissue, a key factor in age-related metabolic dysfunction. The proposed studies aim to characterize the biochemistry and signaling mechanisms underlying this...
- This Project Grant award for $446,875 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to gain genetic insights into cellular senescence using the Drosophila (fruit fly) brain. The project aims to leverage the powerful genetics of Drosophila to identify key drivers of senescence in neurons and glia, with the goal of modulating senescence onset and mitigating associated age-related brain decline. The award is held by the Trustees of the University of...
- This federal Project Grant award of $2,631,670 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research initiative at The Washington University to investigate age-related deficits in episodic memory. The project aims to determine how aging distinctly affects the content and structure of memory representations, and how this relates to dysfunction in different brain networks based on susceptibility to Alzheimer's disease pathology. The research will utilize plasma...
- This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
- This federal Project Grant award of $203,278.00, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund research to understand the behavioral and neurobiological mechanisms underlying age-related shifts in motivation and their impact on daily life activity participation in older adults. The research will employ a multilevel, multimodal approach, utilizing behavioral, psychophysiological, neuroimaging, and naturalistic assessment methods to...
- This Project Grant award from the National Institute on Aging's (NIA) Aging Research program (CFDA 93.866) provides $660,402 to the University of Maryland, Baltimore (UMB) to study the role of autophagy, a cellular process that recycles damaged components, in regulating lipid metabolism and inflammation in microglia during brain aging and neurodegenerative diseases like Alzheimer's disease (AD). The research aims to determine how microglial lipid phagocytosis inhibits autophagy, leading to the...
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- This Project Grant award, with a total funding amount of $878,190.00, was provided by the National Institute on Aging (part of the U.S. Department of Health and Human Services) under the Aging Research federal grant program (CFDA 93.866). The grant is supporting research by the Scripps Research Institute in California to investigate a "druggable mito-nuclear feedback mechanism" that can preserve mitochondrial and synaptic function in aging and age-related dementias like Alzheimer's...
This federal Project Grant award of $2,586,818.00 was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to the Fred Hutchinson Cancer Center in Seattle, Washington. The grant aims to elucidate the mechanisms of communication between adipocytes (fat cells) and the brain, and their impact on glial cell function, neuroprotection, and brain aging. The research will focus on investigating how adipocyte-derived lipoproteins and mitochondrial signals influence glial phagocytic activity and senescence, with potential implications for preventing dementia and age-related cognitive decline. The project will employ genetic manipulation, confocal microscopy, biochemical assays, and high-throughput sequencing in the Drosophila model organism to achieve its objectives over the award period from September 15, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.6m | 9/11/25 |