Project Grant R01HL181513
- This Project Grant award of $3,304,237 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a 40-year longitudinal study examining the links between early life adversity, cumulative life stress, and cellular aging in midlife women and their offspring. The study aims to assess which aspects of life course stress, including childhood, midlife, and cumulative stress, are associated with accelerated cellular aging at age 50. The study will repeat assessments of cell aging...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $771,751 to The University of Texas Southwestern Medical Center to conduct research on the prognostic and predictive impact of telomere length in fibrotic interstitial lung disease. The 5-year project aims to leverage a multicenter cohort of over 4,000 patients to quantify how leukocyte telomere length can inform individual progression and mortality risk, as...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to study the effects of structural racism on disparities in environmental exposures and cardiovascular disease (CVD) outcomes. The $123,368 award to The Research Foundation For The State University Of New York (UEI LVVEB3CF8MB8), effective September 16, 2025 through August 31, 2030, will leverage New York's all-payer hospital database and integrate it with primary data...
- This federal Project Grant award of $113,683 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to characterize the determinants of cellular senescence and epigenetic dysregulation caused by tobacco smoke exposure in the lung. The research aims to: Determine the time- and age-dependent effects of cigarette smoke exposure on lung cellular senescence and associated epigenetic regulation in mouse models. Study the determinants of...
- This Project Grant award of $125,532.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to investigate the disruption of the clonal architecture of human hematopoietic stem cells driven by high-effect somatic and germline genetic variants, and identify the resulting phenotypic changes that lead to impaired stem cell function and increased disease risk with aging. The research will utilize a mitochondrial lineage tracing...
- This $781,268 Project Grant awarded by the National Institute of Environmental Health Sciences (CFDA 93.113 Environmental Health) will fund research at the University of Southern California to investigate the cardiovascular health impacts of environmental exposures to heat stress and wildfire smoke over the life course. The 5-year study, running from June 2025 to April 2030, will leverage the MetaAIR2 cohort of 400 young adults to examine how these exposures, both independently and jointly,...
- This $789,664 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project titled "Dissecting the Cellular and Spatial Tissue Clock of the Human Lung and Peripheral Blood" at the Icahn School of Medicine at Mount Sinai. The project aims to leverage single-cell RNA sequencing and spatial transcriptomics to characterize the effect of age on the cellular microenvironment of the human lung and peripheral blood. The research will...
- This federal Project Grant award of $1,119,410.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a multi-disciplinary research initiative to investigate longitudinal changes in DNA methylation (LC-DNAM) and its relationship to cardiovascular disease (CVD) risk factors and outcomes across four large population-based cohort studies - ARIC, CARDIA, FHS, and MESA. The research aims to: 1)...
- The federal Project Grant award of $108,978.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate the mechanisms underlying the age-related decline in the regenerative capacity of alveolar type 2 (AT2) cells in the lung. The principal investigator and research team at the Harvard T.H. Chan School of Public Health will conduct studies to determine whether elevated interferon gamma (IFNG) levels and changes in resident...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $777,954 to the Icahn School of Medicine at Mount Sinai to conduct research on improving preconception cardiovascular health among adolescents. The key products and services to be delivered through this grant include: Constructing a school-based adolescent preconception cohort through data linkages to study the influence of school environments on cardiovascular risk...
This Project Grant award of $549,128 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a study to investigate the relationship between early-life factors, telomere length, and the development of subclinical atherosclerosis. The research team at The Research Foundation For The State University Of New York (RF SUNY) will measure telomere length from birth to young adulthood and assess its association with growth, air pollution exposure, and subclinical markers of cardiovascular disease. This longitudinal study leverages existing data and biospecimens from the Southern California Children's Health Study to efficiently explore the complex dynamics of biological aging during early life and its impact on later cardiovascular health. The award commenced on August 15, 2025 and is expected to be completed by May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $549.1k | 8/15/25 |