Project Grant RF1AG094765
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Texas Medical Branch at Galveston $1,112,821 under the Aging Research program (CFDA 93.866) for a five-year project period spanning January 1, 2026, through December 31, 2030. This Project Grant supports biomedical research investigating the interplay between microglia activation and tau oligomer polymorphs in cognitive resilience among Alzheimer's disease patients. The research focuses on...
- Federal Grant Award Summary The National Institute on Aging awarded The University of Texas Health Science Center at San Antonio a $433,125 exploratory/developmental project grant on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the role of extracellular tau protein in modulating neurogenesis through the LRP1 (Low-Density Lipoprotein Receptor Related Protein 1) pathway. The research project, with an ultimate completion date of August 31, 2027, will deliver...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $456,500 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for a two-year period beginning February 1, 2026 and concluding January 31, 2028. This research project investigates the role of heparan sulfate proteoglycans (HSPGs) in tau protein uptake as it relates to Alzheimer's disease progression. The research aims to identify the specific heparan sulfate size...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $1.31M Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 1, 2026, with completion targeted for December 31, 2030. This research award supports an investigation into the role of Enhancer of Zeste Homolog 2 (EZH2), an epigenetic modifier, in cerebral amyloid angiopathy (CAA) and Alzheimer's disease (AD). The project will examine how EZH2-mediated...
- Federal Project Grant Award Summary The University of Texas at Austin received a $438,625 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2027. The award funds research investigating the heterogeneity of interneuron vulnerability in aging and Alzheimer's disease using advanced ultraplex correlative light and electron microscopy (CLEM) techniques. The research aims to decode why certain...
- Federal Project Grant Award Summary The University of Texas at Dallas received a $347,657 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 15, 2026, with completion targeted for January 31, 2031. This award supports research investigating a novel astrocyte endfoot protein (AQP4X) arising from translational readthrough and its role in Alzheimer's disease (AD) pathology. The research employs loss-of-function and gain-of-function...
- Federal Grant Award Summary The University of Texas Health Science Center at Houston received a $650,533 Project Grant from the National Institute on Aging (CFDA 93.866: Aging Research) effective February 1, 2026, through January 31, 2031. This research project investigates the contribution of intramural von Willebrand factor (VWF) to cerebrovascular dysfunction in amyloidosis, with particular focus on understanding how VWF accumulation within blood vessel walls promotes abnormal vascular...
- Federal Grant Award Summary The University of Texas at Austin received a $425,986 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on September 15, 2025, with a completion date of August 31, 2027. The grant funds research investigating how apolipoprotein E4 (APOE4) homozygosity affects hippocampal place cell coding and neuronal population dynamics. The research involves recording large populations of place cells in rat models to...
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $3.18 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded August 13, 2025, with completion targeted for July 31, 2029. This award supports research investigating the spatial organization and conformational ensembles of alpha-synuclein (α-syn) amyloids within cellular environments. The project delivers scientific research products...
- Federal Grant Award Summary The University of Texas Health Science Center at San Antonio received a $209,624 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded June 9, 2025, with completion targeted for August 31, 2028. This award supports the development and evaluation of neuroimaging biomarkers for assessing structural and functional network degeneration in Alzheimer's Disease (AD). The project extends the Amyloid-Tau-Neurodegeneration...
The University of Texas Medical Branch at Galveston received a $3.27 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) for the period June 1, 2026 through May 31, 2030. The award supports research investigating the apolipoprotein E (APOE)-tau axis in preeclampsia and its connection to neurodegeneration and Alzheimer's disease and related dementias (ADRD). The research will utilize primary human trophoblast assays, humanized preeclampsia mouse models with APOE2, APOE3, and APOE4 variants, and both predictive and therapeutic approaches to examine proteinopathy and tauopathy mechanisms shared between preeclampsia and neurodegenerative diseases. The project delivers scientific research products and services focused on understanding abnormal lipid metabolism and the APOE-tau axis as critical upstream triggers in the progression of preeclampsia-associated chronic diseases, particularly dementia. Preliminary findings indicate that preeclampsia serum accelerates tau induction in human tau transgenic mice, and that therapeutic intervention with trehalose can reverse these effects. The research will advance knowledge regarding the mechanistic overlap between a significant pregnancy complication affecting 5-8% of pregnancies and age-related neurodegenerative disease, contributing to the NIA's mission of preventing and treating Alzheimer's disease and related dementias.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.3m | 5/19/26 |