Project Grant RF1AG094716
- This $3,109,079 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at the University of California, Riverside to investigate the role of traumatic brain injury (TBI) across the lifespan in the development of Alzheimer's disease and related dementias (ADRD). The project will use a closed head injury (CHI) TBI mouse model to examine how ADRD risk factors, such as the APOE4 gene and amyloid-beta, interact with TBI at different life stages...
- This federal Project Grant award, valued at $3,102,638.00 and spanning August 15, 2024 to July 31, 2027, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to The Trustees of the University of Pennsylvania. The grant aims to develop novel gyrencephalic animal models that can recapitulate the complex neuropathological and clinical features associated with traumatic brain injury (TBI)-induced Alzheimer's disease and related dementias (ADRD). The project will evaluate...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Texas Tech University Health Sciences Center (TTUHSC) is intended to investigate the biological mechanisms underlying the development of age-related diseases following traumatic brain injury (TBI). The $192,737 award, effective April 15, 2025 through March 31, 2028, will support research focused on understanding how interactions between the TBI biomarker UCHL1 and prostaglandins contribute...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $794,341 to the University of Illinois to conduct research on the role of pathogen-induced cellular senescence and blood-brain barrier dysfunction in the development and progression of Alzheimer's disease. The 5-year project aims to leverage experimental mouse models, molecular characterization of endogenous retroviruses, and human induced pluripotent stem cell models to investigate...
- The University of Alabama at Birmingham (UAB) received a $816,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant, titled "POLY(ADP-RIBOSE)-DEPENDENT TDP-43 PATHOLOGY IN OXIDATIVE STRESS (R21)," aims to study the mechanisms by which the TDP-43 protein accumulates in the cytoplasm of neurons under oxidative stress conditions, which is a key pathological process in frontotemporal dementia (FTD) and other...
- This $7.72 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Seattle Institute for Biomedical and Clinical Research will define the role of post-traumatic brain injury sleep disruption and glymphatic dysfunction in the development of Alzheimer's disease and chronic traumatic encephalopathy neuropathology. Over three years, the grantee and three sub-awardees will...
- The University of Alabama at Birmingham (UAB) has been awarded a $1,869,019 Project Grant by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding will support a 3-year research project to investigate the role of circadian rhythms, gut microbiome, and gut-to-brain signaling in the onset and progression of Alzheimer's disease (AD) using a Drosophila (fruit fly) model. Key objectives include determining whether depletion of gut microbiota...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, will fund research at the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to investigate the mechanisms linking traumatic brain injury (TBI) to subsequent neurodegeneration and dementia. The $1,975,262 award will support a 3-year study...
- This $3,039,032 Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) supports research on the potential links between SARS-CoV-2 infection and the initiation or acceleration of Alzheimer's disease and related dementias. The Baylor College of Medicine, a prestigious research institution in Texas, will conduct this work from August 2025 through July 2029. The key objectives are to investigate: (1) the relative contributions of genetic risk factors and...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,283,334.00 to the Morehouse School of Medicine (MSM) to develop and validate a progressive mouse model for Traumatic Brain Injury-related Alzheimer's Disease and Related Dementias (TBI-ADRD). The project aims to systematically screen mouse strains and TBI injury types to identify the optimal model for recapitulating key neuropathological, neurobiochemical, and neurocognitive features of human...
The University of Alabama at Birmingham (UAB) was awarded a $2,663,195 Project Grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate the link between bacterial pneumonia, traumatic brain injury (TBI), and cognitive dysfunction. The research aims to understand how amyloid beta released from pulmonary epithelial cells during bacterial pneumonia, particularly Pseudomonas aeruginosa infection, contributes to neuroinflammation and impairs cognitive function in mice with TBI. The project will run from September 15, 2025 to August 31, 2029 and seek to elucidate the mechanism by which infection-induced amyloid beta accumulation in the brain can lead to long-term cognitive decline, potentially providing insights into the relationship between pneumonia, TBI, and the development of Alzheimer's disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.7m | 9/8/25 |