Project Grant RF1AG090598
- This $1,611,000 federal Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Brigham & Women's Hospital Inc. aims to illuminate the role of somatic mutations in the development of primary tauopathies, a group of neurodegenerative diseases including Alzheimer's. The project will leverage single-cell whole-genome sequencing of human brain tissue to examine somatic mutations in neurons and glia, as well as utilize cellular models to dissect mechanisms...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $848,993.00 to examine tRNA modifications in Alzheimer's disease and related dementias (ADRD). The research aims to investigate how changes in the tRNA epitranscriptome and tRNA translation dynamics contribute to protein misfolding and proteotoxic stress in ADRD. The project will run from September 15, 2025 to May 31, 2030 and is being conducted by the...
- The National Institute on Aging (NIA) awarded a $154,748 Project Grant under the Aging Research program (CFDA 93.866) to Brigham & Women's Hospital Inc. to develop an ultrasensitive blood-based diagnostic tool for accurately determining the presence and severity of Alzheimer's disease (AD). The project aims to utilize single molecule detection to measure low abundance AD protein biomarkers, particularly phosphorylated tau proteins, in blood extracellular vesicles, which can reflect protein...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,858,368.00 to Brigham & Women's Hospital Inc. to support research on the role of the SORL1-retromer biology in the pathogenesis of Alzheimer's disease. The award has an initial term from September 30, 2024 to August 31, 2027. Brigham & Women's Hospital Inc. is a prominent academic medical center and research institution in Boston, Massachusetts, affiliated with Harvard Medical...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This $145,992 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the mechanisms underlying the trans-synaptic spreading of pathological tau in the human brain, and the role of amyloid-beta in modulating this process. The research aims to 1) characterize the molecular mechanisms of bivalent tau oligomer binding to healthy human synapses, as a function of amyloid-beta oligomers, and 2) evaluate how the presence or absence of...
- This $492,250 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to determine if regulatory T cells (Tregs) are dysfunctional in Alzheimer's disease (AD). The grant recipient, Brigham & Women's Hospital, will conduct comprehensive scientific investigations to understand the role of Tregs in AD pathology. This includes isolating and functionally assessing Tregs derived from AD patients to evaluate their potential...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This Project Grant award of $717,709 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to discover cellular mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research combines advanced proteomic techniques, deep learning analyses, and transcriptomic profiling using newly generated human induced pluripotent stem...
- This $784,596 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northeastern University supports comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease and tauopathy models. The project aims to develop a proteogenomic pipeline to globally characterize disease-associated proteins with amino acid substitutions, alternative isoforms, post-translational modifications, and proteolytic cleavages across multiple brain...
The Brigham & Women's Hospital Inc. was awarded a $3,672,952 Project Grant from the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to investigate the role of tRNA-derived fragments (TRFs) in tau pathology associated with Alzheimer's disease (AD) and related tauopathies. The research aims to characterize the small RNA landscape, with a focus on TRFs, at different stages of AD pathology and examine the RNA binding capacity of tau variants. The project will also identify TRFs within pathological tau aggregates and visualize their colocalization with tau pathology in human AD brains. This comprehensive research initiative is intended to advance scientific understanding of the molecular mechanisms underlying tau-mediated neurodegeneration and identify potential therapeutic targets for AD and related dementias. The award period is from September 1, 2025 to August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.7m | 8/26/25 |