This $1,611,000 federal Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Brigham & Women's Hospital Inc. aims to illuminate the role of somatic mutations in the development of primary tauopathies, a group of neurodegenerative diseases including Alzheimer's. The project will leverage single-cell whole-genome sequencing of human brain tissue to examine somatic mutations in neurons and glia, as well as utilize cellular models to dissect mechanisms underlying mutational processes. The work will also probe the relationship between tau protein, somatic mutations, and cell death in primary tauopathies. The results have the potential to advance the understanding of neurodegenerative disease pathogenesis and inform the development of new diagnostic and therapeutic approaches. This 3-year grant award began on September 15, 2023 and is scheduled for completion by August 31, 2026. Brigham & Women's Hospital is a subsidiary of the larger Partners Healthcare System, which has previously served as a subcontractor and subgrantee on federal biomedical research projects.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.6m | 9/12/23 |