Project Grant RF1AG086417
- This Project Grant award of $387,006 from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to understand how indoles derived from commensal gut bacteria can promote mobility and counteract sarcopenia (age-related muscle wasting) in aging animals. The research aims to determine the mechanisms by which indoles regulate muscle protein homeostasis, mitochondrial function, and other cellular pathways to maintain muscle mass and function during...
- This National Institute on Aging (NIA) Project Grant award to Emory University, under the Aging Research program (CFDA 93.866), provides $430,375 to determine whether the microbiome metabolite valerobetaine (VB) promotes a mitochondrial aging phenotype in old mice and to test whether VB antagonizes the beneficial effects of carnitine (acetylcarnitine) on mitochondrial aging. The two-year project, running from September 2023 to September 2025, will conduct experimental studies in young and old...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $381,022 to Emory University to investigate how a highly conserved protein, RhoGAP15B, coordinates signaling pathways involved in stem cell renewal within the intestinal tissue of Drosophila (fruit flies). The overarching goal is to leverage the strength of the researchers' preliminary data to understand how this protein regulates cell division and tissue repair mechanisms, which have...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Massachusetts Medical School is focused on understanding how the gut microbiome influences neurodegeneration and protects against Alzheimer's disease. The $647,979 award, effective September 30, 2024 through August 31, 2025, will leverage the C. elegans model system to: Determine how bacterial production of vitamin B12 protects against neurodegeneration pathways. Examine...
- This Project Grant award of $429,000.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Colorado-Denver aims to investigate the relationship between gut microbiota dynamics, exercise, and physical function among older adults with HIV. The research project will examine how exercise-induced changes in the gut microbiome may contribute to improvements in physical function for this population, which has been observed to experience impairments in physical...
- This federal Project Grant award for $694,824 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) aims to investigate the relationship between the gut microbiome and age-related joint degeneration, or osteoarthritis (OA). The research, conducted by the University of California, San Francisco (UCSF), will focus on examining how changes in the gut microbiome during aging may influence the development of spontaneous, age-related joint degradation. Key...
- This $484,314 Project Grant was awarded by the National Science Foundation (NSF) Division of Integrative Organismal Systems under the Biological Sciences program (CFDA 47.074). The funding will support research at Christopher Newport University to investigate the "microbiota-gut-brain axis" and the impact of intestinal barrier dysfunction on aging and neurodegeneration. Key objectives include gaining insights into the cellular and molecular changes associated with an aging gut, how...
- This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $210,496 to the University of Florida to investigate the role of kynurenine aminotransferases and the aryl hydrocarbon receptor pathway in age-related physical decline. The research aims to test whether elevated kynurenine levels and increased aryl hydrocarbon receptor activity are drivers of the decline in muscle and physical function during aging, using novel genetic...
- This $2,991,725 Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research into the role of reactive oxygen species as modulators of lifespan and age-related diseases. The 4-year project, which commenced on September 1, 2025, aims to investigate a novel longevity paradigm in C. elegans that is triggered by early-life oxidative stress and mediated by changes in the epigenetic landscape. The research will examine the conserved mechanisms...
- This $530,469 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rowan University aims to investigate the role of the protein orosomucoid1 in mitigating age-related muscle loss and dysfunction (sarcopenia). The central hypothesis is that enhancing autophagy (a cellular process) through administering TAT-BECLIN1 and combining it with exercise will boost orosomucoid1 levels and improve muscle function in aged mice. The project seeks to determine if...
This federal Project Grant award of $3,251,767.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Emory University supports research to understand how indoles from commensal gut bacteria can promote mobility and healthspan in aging animals, including mice, fruit flies, and nematodes. The research aims to elucidate the mechanisms by which indoles, acting through the aryl hydrocarbon receptor, can limit sarcopenia and preserve muscle function and mitochondrial health during aging. The award commenced on September 1, 2025 and is scheduled for completion on August 31, 2029. This research project builds on the investigators' previous work demonstrating the beneficial effects of indoles on muscle and mobility in diverse aging model organisms, as well as recent human epidemiological data linking loss of indole-producing gut bacteria to reduced mobility in older adults.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.3m | 8/13/25 |