The National Institute of Neurological Disorders and Stroke (NINDS) awarded Emory University a $430,375 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to study disease-associated mutations and ligand activation of the adhesion G protein-coupled receptor ADGRB2. The key objectives are to: Investigate newly identified patient mutations in the ADGRB2 gene that are associated with spastic paraparesis and other neurological symptoms,...
This three-year, $3.24 million project grant from the National Institutes of Health National Institute on Aging will fund research into the role of clusterin in oligodendrocyte lineage and myelination in Alzheimer's disease. Specifically, the University of Virginia researchers will pursue three aims: 1) determine the mechanisms of clusterin expression and its inhibition of oligodendrocyte progenitor cell differentiation; 2) assess the impact of pathological clusterin expression on myelination,...
This $3.6 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at the Icahn School of Medicine at Mount Sinai directed at understanding the role of glial cell interactions surrounding amyloid plaques in the progression of Alzheimer's disease. As part of the Aging Research program (CFDA 93.866), the three-year award will support investigation of how deletion of the Plexin-B1 gene impacts glial network formation and the...
This $187,500.00 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research focused on exploring the role of the extracellular signaling protein Reelin in Fragile X Syndrome (FXS). The award aims to validate a novel gene therapy approach using an optimized Reelin fragment to completely restore cognitive deficits in an FXS...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $1,853,477 to the Research Foundation for Mental Hygiene, Inc. (RFMH) at the Nathan S. Kline Institute to conduct research on hyperexcitability and interictal spike activity in Alzheimer's disease. The research aims to investigate the origins and mechanisms of these neural phenomena, as well as evaluate whether selectively inhibiting them can improve cognition and reduce...
This $1,823,353 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to the Seattle Institute For Biomedical And Clinical Research aims to elucidate the molecular mechanisms by which pathological tau protein causes neurodegeneration in Alzheimer's disease (AD) and related tauopathy disorders. The research project will leverage a C. elegans model of tauopathy to investigate the functional role of nuclear speckles, membraneless organelles involved in RNA...
This $1,003,116 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project led by the University of Alabama at Birmingham (UAB) to investigate mechanisms of synaptic resilience to tau pathology in Alzheimer's disease. The project aims to identify synaptic proteins and cellular pathways associated with modulating tau seeding, tau-induced synaptic dysfunction, and synapse preservation in Alzheimer's patients who exhibit cognitive...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) is providing $436,775 to Brandeis University to investigate how individual differences in the brain's dopamine system may contribute to resilience against Alzheimer's disease pathology. The key objectives of this 2-year research project are to: Determine if the DRD2 T/T genotype, associated with higher dopamine D2 receptor availability, confers greater cortical thickness despite the presence of...
The National Institutes of Health's National Institute on Aging awarded a $7,432,562 project grant to the Regents of the University of California, San Francisco on September 15, 2022 under the Aging Research program (CFDA 93.866). The grant will support research to elucidate the roles of Alzheimer's disease risk genes and variants in gene expression and AD-related phenotypes through 2025. Specifically, the University of California, San Francisco will use CRISPR and single-cell RNA sequencing...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) in the amount of $1,518,292 will fund a comprehensive study on the regulation of the Alzheimer's disease risk gene TREM2 through alternative splicing. The key objectives are to: 1) characterize the full transcript repertoire of TREM2 in human brain tissue, 2) assess the impact of Alzheimer's-associated TREM2 variants on RNA splicing and post-splicing processing, and 3) analyze the...