This $454,024 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will support research conducted by the Research Foundation For Mental Hygiene, Inc. (RFMH) through its Nathan S Kline Institute Division. The key objectives are: (I) to determine the role of high frequency oscillations (HFOs) as a new biomarker for Alzheimer's disease, (II) to manipulate HFOs in real-time as a method to boost or repress memory, and (III) to test an underlying mechanism...
This $503,887.30 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) aims to elucidate the role of the supramammillary nucleus (SUM) in modulating hippocampal theta rhythms and their relationship to memory deficits in aging and Alzheimer's disease. The project will dissect the SUM-hippocampal circuits, investigate how aging modifies the structure, physiology and function of the SUM circuitry leading to memory impairments, and develop minimally invasive SUM...
This $6,226,692 project grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to The Trustees of Columbia University in the City of New York. The grant will support research examining the role of neuronal hyperexcitability and proteostasis (regulation of protein life cycle) in the early progression of Alzheimer's disease (AD). The study aims to track electrophysiological changes and protein accumulation in the locus coeruleus...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) will fund a $2,332,368 longitudinal study to elucidate the role of neuronal dysfunction and hyperexcitability in the early biological progression of Alzheimer's disease. The 5-year study, awarded to the University of California, San Francisco, aims to identify the earliest manifestations of neural circuit hyperexcitability that predict accumulation of tau pathology and...
This $1,758,779 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research to assess the neuronal vulnerability of excitatory and inhibitory neurons in the entorhinal cortex due to Alzheimer's disease pathology. The research aims to determine whether hyperexcitability in this brain region is caused by dysfunction of excitatory or inhibitory neurons. Using mouse models of Alzheimer's disease, the project will employ optogenetic, chemogenetic, and...
This Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) is providing $107,948 to The Research Foundation for the State University of New York's Upstate Medical Center to conduct research on advancing the diagnosis of Alzheimer's disease. The goal is to use state-of-the-art computational approaches to analyze genetic, epigenetic, and neuroimaging data to identify distinct molecular subtypes of Alzheimer's disease that can be detected through...
This federal Project Grant award from the Department of Health and Human Services' National Institute on Aging (CFDA 93.866 - Aging Research) provides $169,560 to the Regents of the University of Michigan to conduct research aimed at mapping and modeling inhibitory interneurons in Alzheimer's disease and related dementias. The key objectives are to: 1) Identify disrupted interneuron gene expression in human post-mortem Alzheimer's brain tissue, 2) Characterize inhibitory dysfunction of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,413,601.00 to the Research Foundation For Mental Hygiene, Inc. (RFMH) to investigate the role of extracellular vesicles, specifically mitovesicles, in Alzheimer's disease. The research aims to explore the cellular mechanisms involving mitovesicle generation, secretion, uptake, and intracellular fate in recipient brain cells under both physiological and pathological conditions. The study...
This $2,173,794 federal project grant award, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research to investigate the potential for adult hippocampal neurogenesis (AHN) and brain-derived neurotrophic factor (BDNF) to enhance resilience to Alzheimer's disease (AD). The project aims to: 1) explore the mechanisms by which AHN cooperates with BDNF and test whether improving both can ameliorate cognitive dysfunction in tauopathy models; 2)...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop and optimize non-invasive imaging biomarkers to track neuroinflammation in the early stages of Alzheimer's disease (AD). The $812,030 award, effective from December 2024 to November 2029, supports research focused on three key objectives: Investigating the relationship between astrocytic acetate metabolism and astrocyte reactivity in an AD model using deuterium-based magnetic resonance...