Project Grant RF1AG084030

Award Date 6/1/24
Completion Date 5/31/27
Dollars Obligated $2.3M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92093, USA
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This Project Grant award is funded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The $2,319,456 award will support the University of California, San Diego in developing brain organoid models and leveraging multiomics techniques to investigate the mechanisms underlying Alzheimer's disease (AD) onset and progression.

The key products and services to be delivered include:

  1. Derivation of 6 isogenic mutant and 3 mutant-corrected human induced pluripotent stem cell (hiPSC) lines from healthy and familial AD subjects. These cell lines will be used to generate brain organoids that recapitulate key aspects of AD.

  2. Comprehensive molecular and cellular profiling of the brain organoid models at different stages of development using multiomics approaches to identify "endotypes" - disease-causing mechanisms.

  3. Validation of the disease-causing endotypes through genetic perturbation strategies and evaluation of the brain organoid models for therapeutic screening.

The overall objective is to establish reliable and accurate AD model systems to advance the understanding of AD pathogenesis and facilitate the development of effective therapeutic interventions.

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