Project Grant RF1AG079141
- This three-year, $4,349,236 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The University of South Florida will investigate the role of the BIN1 gene in modulating Alzheimer's disease tau neuropathology in vivo. Researchers will generate cell-type specific inducible BIN1 knockout mice to characterize tau pathogenesis using longitudinal MRI and neuropathology. They will test...
- This $466,531 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by Texas A&M AgriLife Research to investigate the role of the BIN1 protein in oligodendrocytes and its impact on axon integrity. The research aims to provide new insights into how the BIN1 genetic risk factor may relate to the onset and progression of late-onset Alzheimer's disease. The project will utilize oligodendrocyte-specific BIN1 knockout mice and a...
- The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $1,684,689 project grant to Weill Medical College of Cornell University to study the role of microglial lysosomes in the degradation of amyloid-beta, a key pathological feature of Alzheimer's disease. The 3-year project aims to characterize the process of "digestive exophagy" used by microglia to limit the expansion of amyloid-beta plaques, as well as explore the effects of genetic...
- The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...
- This $2,170,748 federal project grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research program), supports research to investigate the functional role of the BIN1 protein in oligodendrocytes and its impact on myelin and axonal integrity under normal aging and Alzheimer's disease conditions. The research will utilize oligodendrocyte-specific BIN1 conditional knockout mice to study BIN1-associated physiological functions in oligodendrocytes and the effects on...
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- This $3.6 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at the Icahn School of Medicine at Mount Sinai directed at understanding the role of glial cell interactions surrounding amyloid plaques in the progression of Alzheimer's disease. As part of the Aging Research program (CFDA 93.866), the three-year award will support investigation of how deletion of the Plexin-B1 gene impacts glial network formation and the...
- This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
- This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $3,018,210 to Baylor College of Medicine under the Aging Research program (CFDA 93.866). The grant funds research to functionally dissect a promising transcriptional regulatory network linked to glutamate excitatory signaling that is downregulated in Alzheimer's disease and enriched for suppressors of neurodegeneration. Researchers will perform genetic manipulations in...
- The University of South Florida (USF) was awarded a $3,297,926 project grant from the National Institute on Aging (CFDA 93.866 - Aging Research) to develop novel biomaterials that can prevent, halt, and potentially cure Alzheimer's disease (AD). The objective of this 4-year project is to advance USF's preliminary work on designing peptide hybrid biomaterials that can stabilize the helical conformation of the amyloid-beta (Aβ) peptide, thereby shifting the equilibrium of Aβ aggregation away...
This three-year, $4.5 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The University of South Florida will investigate the role of the BIN1 gene in Alzheimer's disease pathogenesis and neuroinflammatory signaling by microglia. Researchers will generate mouse models lacking BIN1 specifically in microglia to study effects on amyloid plaque burden, tau pathology propagation, and the modulation of disease-associated microglia transition and neuroinflammation. Comprehensive analyses include biochemistry, neuropathology, transcriptomics, and proteomics. Yale University and Emory University will receive subawards of $450,000 each to support complementary aims investigating microglial BIN1 function in Alzheimer's disease and inflammatory signaling. Outcomes seek to further the understanding of BIN1 as a major genetic risk factor and guide future study of molecular pathways regulated in the disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.3m | 9/9/22 | ||
| Not listed | $2.3m | 9/9/22 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
6144133600BMOD2S | Yale Univ | Project Grant RF1AG079141 | $231.4k | 10/21/24 | |
6144133600BMOD1S | Yale Univ | Project Grant RF1AG079141 | $133.1k | 2/21/24 | |
6144133600BS | Yale Univ | Project Grant RF1AG079141 | $231.4k | 11/17/23 | |
6144133600AS | Emory University | Project Grant RF1AG079141 | $231.4k | 2/16/23 |