Project Grant RF1AG078340
Award Date
9/30/22
Completion Date
8/31/25
Dollars Obligated
$4.7M
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Davis, CA, USA
Similar Awards
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $109,595 to the University of California, Davis (UC Davis) to conduct microscopic studies and behavioral analysis on a novel Alzheimer's disease monkey model. Specifically, the project aims to: Comprehensively characterize the regional and laminar patterns of tau-based neuropathology and neuronal loss within the entorhinal cortex, hippocampus, and neocortical regions of the monkey brain at 12...
The National Institute on Aging awarded a $433,950 Project Grant (CFDA 93.866 - Aging Research) to the University of California, Davis to develop a lifespan rhesus monkey model for studying interoception, the ability to sense and process internal physiological signals. The project aims to establish a translatable animal model for interoceptive processes that deteriorate with aging, which is critical for understanding the neurobiological mechanisms and developing interventions for...
This $689,525 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a research project titled "Connecting Across Scales: Integration of Cell-Specific Microstructure within Long-Range Brain Networks in the Macaque Monkey." The award will support a collaborative study led by the New York University School of Medicine, with a sub-award to the University of California, Davis, to investigate the relationship between cellular-level...
The University of California Irvine will receive $4,522,968 over three years from the National Institutes of Health National Institute on Aging under the Aging Research grant program (CFDA 93.866) to investigate the temporal, spatial and cellular dynamics of amyloid plaque deposition in Alzheimer's disease. The research will utilize cutting-edge biorthogonal non-canonical amino acid tagging technology and cell-specific Cre driver mouse lines to label the proteomes of specific cell types and...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 - Aging Research provides $2,288,327 to the University of California, San Diego (UCSD) to investigate early determinants of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patients. The research aims to better understand the intersection of polygenic risk factors, biological aging, and key molecular pathways that initiate and drive MCI, with the goal of...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $6,226,692 to The Trustees of Columbia University in the City of New York to investigate the role of neuronal hyperexcitability and proteostasis (protein homeostasis) in the early stages of Alzheimer's disease (AD). The research will use a mouse model to examine how modifications in brain activity, specifically in the locus coeruleus and hippocampus, can lead to the pathological...
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...
This $4.49 million project grant from the National Institutes of Health's National Institute on Aging will fund research at The Washington University to investigate the relationship between amyloid plaque deposition, cellular metabolic dysfunction, and functional brain organization in Alzheimer's disease (AD) mice models. Over three years, the researchers will use multi-photon fluorescence lifetime imaging microscopy, multi-parametric photoacoustic microscopy, and wide-field optical imaging to...
This federal Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 (Aging Research) supports research to investigate neural circuit dysfunction in the lateral entorhinal cortex (LEC) of an Alzheimer's disease (AD) mouse model. The $1,566,554 grant awarded to the University of California, Irvine aims to determine: 1) the cell types exhibiting activity dysfunction in the LEC, 2) whether LEC dopamine dysfunction causes memory impairment, and 3) if LEC...
This Project Grant from the National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $5,006,006 to Yale University to support multimodal imaging research aimed at better understanding Alzheimer's disease pathogenesis and treatment response. Specifically, the award will fund research leveraging positron emission tomography, wide-field calcium imaging, and functional magnetic resonance imaging to map changes in excitatory and inhibitory...