The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $1,684,689 project grant to Weill Medical College of Cornell University to study the role of microglial lysosomes in the degradation of amyloid-beta, a key pathological feature of Alzheimer's disease. The 3-year project aims to characterize the process of "digestive exophagy" used by microglia to limit the expansion of amyloid-beta plaques, as well as explore the effects of genetic mutations linked to Alzheimer's on this process. Additionally, the research will examine whether the secretion of lysosomal contents during digestive exophagy contributes to the spread of tau and amyloid-beta fibrils. The project leverages primary mouse microglia and human iPSC-derived microglial cells to advance the understanding of microglial function in Alzheimer's disease pathogenesis, with the goal of informing future therapeutic strategies.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.7m | 8/16/23 |