Project Grant RF1AG076692

Award Date 5/1/22
Completion Date 4/30/25
Dollars Obligated $4.5M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
The National Institute on Aging (NIA) awarded New York University a $254,250 Project Grant under the Aging Research federal grant program (CFDA 93.866) to develop a biologically-relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The project aims to bridge the gap between microscopic and macroscopic brain changes to disentangle the roles of neuroinflammation and neurodegeneration in Alzheimer's disease and related dementias. The researchers will create a...
This Project Grant award from the Department of Health and Human Services' National Institute on Aging (CFDA 93.866 - Aging Research) will provide $419,170 to the University of Maryland, College Park to conduct research on the biophysical properties of lymph nodes and how they change with aging. The researchers will use advanced microscopy techniques, including multiple particle tracking and Brillouin microscopy, to measure the elastic, viscous, and stiffness properties of lymph node tissue in...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,215,724 to the University of California, San Diego (UCSD) for a project titled "INTRINSIC CSF OUTFLOW METRICS FOR MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE." The award aims to develop a novel, non-invasive MRI technique to study intrinsic cerebrospinal fluid (CSF) outflow metrics in healthy older adults, individuals with mild cognitive impairment (MCI), and those...
This federal Project Grant award of $2,461,369.00, awarded by the National Institute on Aging (part of the Department of Health and Human Services) under the Aging Research Federal Grant Program (CFDA 93.866), aims to establish mechanisms for rejuvenating brain lymphatics and exploit brain lymphatic activation as a new therapeutic strategy for craniosynostosis and Alzheimer's disease. The key products and services to be delivered under this 3-year grant include: Developing an animal model...
The National Institute on Aging (NIA) awarded a $513,957 Project Grant (CFDA 93.866 - Aging Research) to the Sloan-Kettering Institute for Cancer Research in New York, NY. The grant, titled "Role of Lymphatic Endothelial Cell NFκB Signaling in Adult Lymph Node Homeostasis," aims to understand the cellular mechanisms that regulate lymph node maintenance in aging. The research will utilize single-cell RNA sequencing and inducible transgenic mouse models to investigate how decreased...
The National Institute on Aging, part of the Department of Health and Human Services, awarded $2,459,487 under its Aging Research grant program (CFDA 93.866) to Seattle Children's Hospital on May 15, 2022 for a project concluding on April 30, 2025. The award will support research using in vivo multi-photon imaging techniques to investigate age-related impairment of venous drainage in deep gray and white matter regions of the mouse brain. Specifically, the researchers will test hypotheses about...
The National Institute on Aging (NIA) awarded a $433,125 project grant under CFDA Program 93.866 (Aging Research) to the Regents of the University of California at Riverside (UC Riverside). The award will fund a 2-year research project to use novel magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques to characterize age-related neuroinflammation and its relationship to memory performance. Key objectives include: Testing whether older age is associated with higher MRS-derived...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,580,676 in funding to the University of Colorado-Denver to conduct a 5-year research study on the effects of aerobic exercise training on peripheral and cerebral vascular function in adults across different age groups and between men and women. The key products and services to be delivered under this award include: Conducting a randomized controlled 12-week aerobic exercise intervention in...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,155,695.00 to The Salk Institute for Biological Studies to investigate the function and metabolism of aging lipids in the brain. The research aims to understand how age-related changes in brain lipid composition, particularly regarding a novel class of anti-inflammatory lipids called 3-sulfo galactosyl diacylglycerols (SGDGs), contribute to aging and neurodegenerative diseases. The...
The National Institute on Aging (NIA), part of the Department of Health and Human Services National Institutes of Health, awarded a $3.37 million Project Grant to The University of Texas at Arlington to develop an individualized deep connectome framework for Alzheimer's disease and related dementias (ADRD) analysis. The three-year grant, awarded on August 18, 2022 under the NIA's Aging Research program (CFDA 93.866), will support research to discover and identify individualized...

This three-year Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $4.5 million to study the effects of aging and exercise on dural lymphatic clearance in healthy and diabetic human brains under the Aging Research program (CFDA 93.866). The University of California, San Diego will use non-invasive MRI techniques to examine dural lymphatic perfusion at the meninges in healthy subjects and compare results to age- and sex-matched adults with diabetes mellitus. The research aims to clarify dural lymphatic anatomy, identify clearance pathways, obtain perfusion measures, and evaluate the impacts of age and exercise. Findings could provide insights into how reduced lymphatic clearance may contribute to cognitive decline associated with aging and diabetes.

Generated 1/6/24, 4:00 PM