Project Grant RF1AG074346

Award Date 6/1/22
Completion Date 5/31/25
Dollars Obligated $2.1M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Cleveland, OH 44106, USA
Similar Awards
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Case Western Reserve University aims to evaluate the therapeutic potential of CHCHD10 antagonists and delineate the interplay between CHCHD10, mitochondria-associated ER membranes (MAM), and mitophagy in mitigating Alzheimer's disease pathogenesis. The $3,077,305 award, with a project period from August 1, 2024 to April 30, 2029, will support research to assess the protective effects of the CHCHD10...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,156,262.00 to Case Western Reserve University's Office of Research Administration Division (doing business as University Hospitals of Cleveland) to conduct research on the role of N6-methyladenosine (m6A) RNA modification dysregulation in the pathogenesis of Alzheimer's disease. The research aims to determine how reduced expression of the m6A methyltransferase enzyme METTL3...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Case Western Reserve University will support research to determine the pathogenic role of the APP E590D variant in Alzheimer's disease. The $788,900 award, with a project period from August 15, 2024 to May 31, 2026, will fund studies to: 1) identify a new C-terminal cleavage site of the amyloid precursor protein (APP) beyond the beta-secretase cleavage site using mass spectrometry, and 2) generate...
This $342,934.65 project grant from the Department of Health and Human Services National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease. The Trustees of Columbia University in the City of New York, doing business as Health Sciences Division, will analyze lipid composition in brain regions susceptible to Alzheimer's disease, such as the...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) program, provides $644,000 to Case Western Reserve University to investigate the role of RNA N6-methyladenosine (m6A) modification in the metabolism of amyloid-beta (Aβ) and its contribution to Alzheimer's disease pathology. The researchers aim to determine how reduced METTL3-mediated m6A methylation affects mRNA stability, translation, splicing, and nuclear export of genes involved in...
The National Institute on Aging awarded Case Western Reserve University $1,785,220 under the Aging Research program (CFDA 93.866) from May 2022 to April 2025. The university will research the role of deubiquitinase USP19 in the pathogenesis of TDP-43, a protein implicated in neurodegenerative diseases like frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Using mouse models, human post-mortem tissues, and molecular and cell biology techniques, the university aims to validate...
This three-year, $4.68 million Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will support research into the collision of Alzheimer's disease and the COVID-19 pandemic in the United States. Funded under the Aging Research program, the grantee Case Western Reserve University will utilize a nationwide electronic health records database of over 80 million patients to examine COVID-19 risks and outcomes for those with Alzheimer's, including...
This Project Grant award, with Federal Grant ID R01AG082382, was provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) federal grant program. The total funding amount is $3,038,050.00 and the award period runs from August 15, 2024 to May 31, 2029. The grant supports research conducted by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to investigate the role of oxidative stress pathways and microglial dysfunction in the...
The National Institute on Aging (NIA) awarded a $802,034 Project Grant under the Aging Research (CFDA 93.866) federal grant program to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The grant aims to develop a multimodal, multiscale, and multistage systems biology (M3SB) infrastructure to advance precision medicine for Alzheimer's disease (AD) and longevity. Key activities include: 1) Conducting multi-modal analyses of genetics, multi-omics data,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $575,667 to the University of Mississippi Medical Center to conduct research on the role of activated protein C (APC) signaling in the pathogenesis of Alzheimer's disease (AD). The project aims to characterize how APC signaling impacts the metabolic and inflammatory processes underlying AD, as well as evaluate the potential of APC derivatives to improve neurological function in AD. A...

This three-year Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund $2,136,033 in research under the Aging Research program (CFDA 93.866). The grant recipient, Case Western Reserve University in partnership with University Hospitals of Cleveland, will investigate the role of the CHCHD6 protein in Alzheimer's disease pathology and potential therapeutic interventions. Specifically, the researchers will study the causes and consequences of CHCHD6 dysfunction in Alzheimer's disease models, determine the mechanisms by which CHCHD6 loss contributes to Alzheimer's pathology, and assess whether restoring CHCHD6 function can alleviate neuropathology and cognitive deficits in Alzheimer's mice models. If successful, this research aims to establish CHCHD6 as a key molecule linking amyloid precursor protein processing, lipid disturbances, and mitochondrial dysfunction in Alzheimer's disease. Findings could advance understanding of Alzheimer's pathology and identify CHCHD6 as a novel treatment target.

Generated 1/6/24, 7:39 PM