Project Grant RC2DK144739
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $672,737 Project Grant to the University of California, Los Angeles (UCLA) on August 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The research will be conducted through July 31, 2030, at UCLA's Los Angeles campus. This award supports basic biomedical research investigating the molecular mechanisms by which...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases awarded a $128,235 Project Grant to the University of California, Los Angeles (UCLA) on September 13, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This award funds basic biomedical research investigating the mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) across multiple metabolic tissues, including subcutaneous...
- Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Broad Institute, Inc. $882,180 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) beginning September 19, 2025, with completion scheduled for May 31, 2030. This Project Grant supports massive-scale genomic risk assessment to inform precision medicine across the spectrum of monogenic and common forms of diabetes. The primary deliverables...
- The University of California, Los Angeles, received a $1.57 million Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective August 28, 2025, through June 30, 2029. This research project investigates post-transcriptional regulation of hepatokines—secreted peptides produced by the liver that coordinate systemic metabolism—and their role in maintaining...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1.48 million Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Colorado-Denver on September 5, 2025, with completion targeted for June 30, 2030. The project, titled "Extending Inferences of Efficacy and Selection of Transformative Diabetes Therapies to Diverse Populations," addresses critical...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded $167,363 to the University of California, Los Angeles under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on March 1, 2026. This five-year Project Grant, with a completion date of February 28, 2031, supports fundamental biomedical research investigating novel central nervous system (CNS) mechanisms relevant to obesity and metabolic dysfunction....
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases awarded a Project Grant of $778,662 to the University of California, Los Angeles (awarded April 6, 2026; completion January 31, 2030) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The project investigates the genetic and microbial regulation of indole-3-propionic acid (IPA), a bacterial metabolite derived from dietary tryptophan, and its...
- Federal Project Grant Award Summary The University of California, Los Angeles received a $1.52M Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 1, 2025, with completion targeted for May 31, 2030. This award funds biomedical research designed to elucidate the molecular mechanisms regulating lipid flux in cells and animals and their...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of North Carolina at Chapel Hill a $1.62 million Project Grant (CFDA 93.847: Diabetes, Digestive, and Kidney Diseases Extramural Research) on September 22, 2025, for a project period extending through June 30, 2030. The grant funds development of resources to interpret genetic signals and identify multi-tissue regulatory mechanisms underlying type 2 diabetes (T2D) and...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of California Irvine $776,971 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on June 5, 2026, for a project grant extending through March 31, 2031. This research initiative investigates the biological mechanisms linking early life stress (ELS), particularly prenatal stress exposure, to the developmental programming of...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1.58 million Project Grant to the University of California, Los Angeles (UCLA) on July 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds the NIDDK HERITAGE study, a research initiative designed to develop comprehensive tandem repeat (TR) resources and advance understanding of the genetic architecture underlying diabetes and obesity. Spanning through March 31, 2031, the project leverages existing whole-genome sequencing data from diabetes and obesity cohorts to establish a tandem repeat atlas and conduct tandem repeat genome-wide association studies (TR-GWAS) to identify previously unrecognized genetic contributors to metabolic disorders. The deliverables under this grant include the creation of a TR atlas resource and the application of innovative computational tools to elucidate the molecular mechanisms through which tandem repeat variations impact diabetes and obesity phenotypes. By integrating expertise in metabolic biology, bioinformatics, and population genetics, UCLA will validate causal effects of tandem repeats across multi-ancestry populations, addressing the significant gap in understanding genetic heterogeneity that accounts for approximately 80% heritability in these metabolic disorders yet remains largely unexplained by current single nucleotide polymorphism-based approaches.Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.6m | 7/16/26 |