Project Grant R61HD118439
- This Project Grant award from the Department of Health and Human Services National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) provides $446,096 to the University of Illinois to develop and implement community-based participatory health research with young adults with Down syndrome. The project aims to reflect the perspectives and lived experiences of adults with Down syndrome, including those from underserved and underrepresented communities, to reduce health disparities and...
- The National Institute of Child Health and Human Development (NICHD) awarded a $163,813 Project Grant to the University of Colorado-Denver (UCD) for the project "Improving Health Care Communication and Engagement for Adults with Down Syndrome." The 5-year grant, starting on September 3, 2025, aims to address health disparities experienced by individuals with Down syndrome by developing and piloting a patient-and-supporter-driven communication tool tailored for adults with Down...
- This $116,685 federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 - Child Health and Human Development Extramural Research will support research to understand the needs of children with Down syndrome who have survived leukemia and their families during the reintegration process. The award recipient, the University of Wisconsin System, will conduct a convergent mixed methods study to examine the...
- This $2,598,199 Cooperative Agreement, awarded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), will support a multi-center, multi-disciplinary research project titled "Advancing the Lives & Health of Youth and Young Adults with Down Syndrome (ALLY-DS)." The project aims to establish a diverse cohort of individuals with Down syndrome for comprehensive longitudinal phenotyping, including multi-omics data...
- This Cooperative Agreement award, funded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), will support a 5-year, longitudinal study entitled "Metabolic Health, Lifestyle, and Risk of Co-Occurring Health Conditions in Down Syndrome (MET-DS)". The study will enroll 200 participants aged 6-24 years with Down syndrome across 4 clinical sites to deeply characterize metabolic health, obesity, and lifestyle...
- The federal Project Grant award of $674,338 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to evaluate the impact of a cooking skills intervention combined with a multicomponent weight management program on long-term weight loss in young adults (age 18-26) with intellectual disabilities (ID), especially those with Down syndrome. The award recipient, the University...
- The Trustees of the University of Pennsylvania received a $3.7 million Project Grant award from the Department of Health and Human Services National Institutes of Health Office of the Director to address co-occurring conditions in individuals with Down syndrome. Funded under the Trans-NIH Research Support program (CFDA 93.310), the three-year project will test whether reducing proteostatic stress with the FDA-approved small molecule 4-phenylbutyrate can ameliorate sleep deficits, metabolic...
- The Project Grant award of $451,000.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) is funding research at the University of Texas Southwestern Medical Center (UT Southwestern) to identify genes on human chromosome 21 that contribute to the neurological and developmental impairments associated with Down syndrome. The 2-year project will use CRISPR interference (CRISPRi) technology and induced pluripotent stem cells (iPSCs) derived from individuals...
- The federal Cooperative Agreement award U01HD116463, titled "The Infant Down Syndrome Brain and Behavior Study", is funded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The $2,927,457 award will support a longitudinal study to collect multimodal neuroimaging, cognitive/behavioral data, and social communication measures in a cohort of 100 infants with Down syndrome and 50 typically developing controls. The study aims to...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) is providing $661,575 to Children's Hospital Los Angeles to conduct a 5-year study on Down Syndrome Regression Disorder (DSRD). The principal investigator, Dr. Jonathan D. Santoro, is an international expert on DSRD, a neuropsychiatric condition in individuals with Down Syndrome that causes severe...
The U.S. Department of Health and Human Services, National Institutes of Health (NIH) awarded a $1,017,548 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the University of North Carolina at Chapel Hill. The grant, titled "HOME GROWN: A FAMILY-BASED LIFESTYLE INTERVENTION TO SUPPORT HEALTHY DEVELOPMENT OF YOUNG CHILDREN WITH DOWN SYNDROME," will fund a 2-phase study to evaluate the feasibility (R61 phase) and efficacy (R33 phase) of a tailored healthy lifestyle program for families of young children with Down syndrome. The goal is to improve healthy eating and physical activity practices in this population, which experiences disproportionately higher rates of chronic health conditions compared to typically developing peers. The R61 phase will assess feasibility with 38 primary caregivers, while the R33 phase will evaluate program efficacy with 208 caregivers. Key outcomes include children's diet quality, physical activity, and families' use of evidence-based healthy practices. The project aims to develop an accessible, family-based prevention and control program to support the overall well-being of young children with Down syndrome.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 8/7/25 |