Project Grant R21AI185699
- This federal Project Grant award, valued at $231,934.00, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports the development of a new modular platform technology that mimics lymph nodes to improve the engineering of T cells for cellular immunotherapy. The funded research aims to create biomimetic scaffolds that can...
- The federal Project Grant award of $3,436,588.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The award supports research to investigate the role of the TLE3 transcription cofactor in regulating the function and persistence of CD8+ T cells during chronic viral infections and cancer. The research aims to molecularly reconstruct the T cell exhaustion process and identify therapeutic...
- This federal Project Grant award of $246,750 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports a research study on the "Transcriptional and Functional Identity of Human T Follicular Helper Cells Across Tissues". The project aims to conduct a systematic analysis of human T follicular helper (Tfh) cells across lymphoid and mucosal tissues, including the lung, in order to define how T cells influence...
- This $858,186 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports a research project titled "Decoding T Cell Clonotypes, Biology and Predictive Biomarkers Associated with Immune Checkpoint Myocarditis." The project aims to investigate the mechanisms underlying immune-related myocarditis, a potentially fatal adverse event associated with immune checkpoint inhibitor cancer therapies. Using...
- This $300,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports the development of a GMP-compliant E. coli dihydrofolate reductase (EDHFR) vector. This vector will be used to monitor the biodistribution and trafficking of investigational chimeric antigen receptor (CAR) T cell therapies through positron emission tomography (PET) imaging. The goals are to provide a...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $372,100 to the University of Wisconsin - Madison to develop novel "mechanoimaging" technologies that can measure and program piconewton-scale mechanical forces exerted by individual cell receptors in viscoelastic biomaterials. The goal is to quantify how cells, including fibroblasts, cancer cells, and T cells, physically...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $222,708 Project Grant to The Trustees of Columbia University in the City of New York under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant, which runs from May 1, 2025 to December 31, 2028, will support research to develop self-assembling modular hydrogels that can programmably display glycan ligands to direct immune cell phenotypes. This...
- The Project Grant award of $806,693.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports a research project at New York University (NYU) titled "LYMPHATIC CONTROL OF GERMINAL CENTERS." The project aims to investigate the role of the lymphatic vasculature in regulating immune responses, with a focus on understanding how lymphangiogenesis (growth of new lymphatic vessels) shapes...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $253,497 Project Grant under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855) to The Trustees of Columbia University in the City of New York for the project "MOBILIZING INNOVATIVE STRATEGIES TO IMPROVE TB DIAGNOSIS AND RETENTION IN THE TB CARE CASCADE FOR MIGRANT COMMUNITIES IN NEW YORK CITY". The project aims to evaluate innovative methods, including a mobile diagnostic platform...
- This federal Project Grant award of $658,657, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research at the University of Virginia on the biophysical and functional coupling of protein condensates to ordered lipid domains in T-cells. The research aims to reveal the mechanisms by which protein condensates and membrane domains cooperatively regulate T-cell signal transduction and...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $239,135 to develop a new magnetics-based method for rapidly mapping the mechanical properties of tissues. The goal is to address technical limitations of current scanning probe methods used to study the tumor microenvironment and its impact on T cell function in solid tumors. The award will fund the development and validation of the new mapping platform, as well as its initial application to advance two strategic research areas. Successful completion of this developmental/exploratory study is a key proof-of-principle for this novel approach, which can then be further applied to reveal the influence of tumor mechanics on immunotherapy. The project will be conducted by The Trustees of Columbia University in the City of New York and is set to run from August 2025 through July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $239.1k | 8/11/25 |