Project Grant R61AT012270

Award Date 9/12/24
Completion Date 8/31/26
Dollars Obligated $1.7M
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
New York, NY 10065, USA
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This Project Grant award from the National Institute of Neurological Disorders and Stroke (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $1,702,003.00 to Weill Medical College of Cornell University over the period from September 12, 2024 to August 31, 2026. The grant aims to develop and clinically evaluate a quantitative imaging biomarker for assessing masticatory myofascial pain syndrome (MMPS), which afflicts nearly 10% of Americans. The key products and services funded through this award include:

  1. Developing and optimizing a 15-minute MRI protocol and processing pipeline to robustly estimate parameters of the Random Permeable Barrier Model (RPBM), which can measure changes in myofiber diameter, sarcolemma permeability, and sarcomere length associated with MMPS.

  2. Establishing an optimal MRI protocol that combines the RPBM method with conventional quantitative MRI measures (T1, T2, fat fraction) and evaluating their repeatability and reproducibility.

  3. Assessing the diagnostic performance of the RPBM parameters to evaluate and predict treatment response in MMPS patients.

The project involves a sub-award to New York University Grossman School of Medicine to provide leadership on the technical development of the RPBM method and oversee experiments conducted at the NYU site.

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