Project Grant R61AI197819
- Federal Project Grant Award Summary Tufts University School of Medicine received a $531,688 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 1, 2026 through May 31, 2028. The award supports development of a next-generation pan-serotype antitoxin for botulinum neurotoxin (BONT) exposures using heteromultimeric camelid single-domain antibodies (VHHs or nanobodies)...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $502,528 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period June 1, 2026 through May 31, 2028. The project focuses on developing next-generation protein neurotherapeutics to treat botulism poisoning caused by botulinum neurotoxins (BoNTs). The research addresses a critical public health...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a Project Grant of $489,500 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 24, 2025, with a completion date of June 30, 2027. The award funds structural research aimed at determining the high-resolution three-dimensional structure of the full-length nucleocapsid (N) protein of Severe Acute Respiratory Syndrome Coronavirus 2...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Regents of the University of California, San Francisco a Project Grant totaling $491,985 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period June 4, 2026, through May 31, 2028. This award supports the development of a fully recombinant, heptavalent botulinum antitoxin utilizing engineered dual variable domain immunoglobulin G1 (DVD-IGG1) monoclonal...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a $889,519 Project Grant effective April 1, 2026, through March 31, 2031, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award supports research and development of a multi-biologic, adeno-associated virus (AAV)-deliverable HIV-1 functional cure utilizing broadly neutralizing antibodies (BNAbs) and ECD4-IG, an antibody-like...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $122,472 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Boston Children's Hospital on August 13, 2025, with a completion date of July 31, 2027. This award supports investigator-initiated research aimed at elucidating the molecular mechanisms underlying the activation and regulation of the NLRP3 inflammasome, a critical component of the...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a $489,500 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) effective August 1, 2025, with completion targeted for July 31, 2027. This award funds biomedical research aimed at identifying and characterizing novel antifungal drug targets within Candida albicans cell wall stress response pathways. The research focuses on the Target...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital a Project Grant of $124,992 under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period May 15, 2026, through April 30, 2028. This award supports investigator-initiated research dissecting the priming and activation mechanisms of the NLRP3 (NOD-like receptor family pyrin domain containing 3) inflammasome in the context of sterile...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded Boston Children's Hospital $151,040 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on December 4, 2025, to support a project extending through July 31, 2028. This Project Grant funds basic science research investigating the regulatory mechanisms of a small regulatory RNA (sRNA) designated BECO in Pseudomonas aeruginosa, a gram-negative bacterium that causes serious...
- Federal Project Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $815,378 Project Grant to the Trustees of Boston University (Boston University Medical Campus) effective May 1, 2026, through April 30, 2031, under the Allergy and Infectious Diseases Research program (CFDA 93.855). The research initiative focuses on identifying and characterizing high-affinity germline-encoded antibodies that can neutralize viral pathogens causing significant...
Boston Children's Hospital received a $534,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 1, 2026, through May 31, 2028. The award supports the development of novel delivery systems and therapeutic proteins designed to reverse botulinum neurotoxin (BoNT) intoxication within neurons. The research addresses a critical biodefense need by developing post-symptom inhibitors that can block BoNT activity after neuronal entry, for which no current therapeutic options exist. The funded research encompasses two primary objectives during the exploratory R61 phase: (1) designing and evaluating a new generation of intraneuronal delivery proteins based on novel BoNT-like toxins superior to previously available variants; and (2) screening and identifying newly generated nanobodies with enhanced binding affinity and neutralization efficacy against BoNT/A and BoNT/B serotypes. The project culminates in the development of at least one improved therapeutic protein capable of reversing BoNT intoxication, with subsequent collaboration planned with the Biological Process Development Facility at the University of Nebraska to advance the lead protein toward clinical translation.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $534.0k | 5/22/26 |