Project Grant R61AG101363
- Federal Project Grant Award Summary Yale University received a $461,146 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on May 15, 2025, with completion targeted for April 30, 2027. The award funds research investigating the dysregulation of cortical astrocytes in Alzheimer's disease (AD) models. The primary deliverable is novel scientific research employing advanced mesoscopic imaging techniques to longitudinally measure...
- Federal Grant Award Summary Yale University received a $746,160 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on March 20, 2026, with completion targeted for February 28, 2031. The grant funds research investigating how peripheral inflammation interacts with aging to increase dementia risk. The research will generate scientific knowledge regarding the cellular and molecular mechanisms through which acute and chronic peripheral immune...
- Federal Grant Award Summary Yale University received a Project Grant of $544,318 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 1, 2026 through May 31, 2031. This research award supports an investigation into immunometabolic regulation of inflammaging through the study of nerve-associated macrophages (NAMs). The project will deliver scientific knowledge regarding how NAMs—specialized immune cells residing on sympathetic nerve...
- Federal Grant Award Summary Yale University received a $461,146 Project Grant from the National Institute on Aging (CFDA 93.866 – Aging Research program) awarded May 15, 2025, with a completion date of April 30, 2027. The award funds research targeting isoform-specific Fibroblast Growth Factor Receptor (FGFR) signaling in Idiopathic Pulmonary Fibrosis (IPF), a chronic progressive lung disease predominantly affecting adults over 65 years of age. The research addresses a significant clinical need,...
- Federal Grant Award Summary Yale University received a $921,822 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded June 9, 2025, with completion targeted for May 31, 2027. The grant funds research investigating lysosomal regulation and functions of Tank-Binding Kinase 1 (TBK1) in neurodegenerative diseases, specifically amyotrophic lateral sclerosis and frontotemporal dementia. The research will deliver molecular and mechanistic insights...
- Federal Grant Award Summary Yale University received a $461,146 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded May 15, 2025, with completion targeted for April 30, 2027. The project, titled "Toward Developing a Navigation Model of the Aging Brain in the Marmoset," focuses on understanding the physiological function and organization of the entorhinal cortex (ERC) in marmosets to advance knowledge of Alzheimer's disease pathology...
- Federal Project Grant Award Summary Yale University received a $681,277 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded May 15, 2026, with a completion date of April 30, 2031. This grant funds research investigating cell size inheritance and innate immune memory, with particular focus on understanding how enlarged immune cells maintain proliferative capacity without transitioning into senescence. The research examines the role of...
- Federal Project Grant Award Summary Yale University received a $265,572 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded August 15, 2025, with completion targeted for June 30, 2027. This research initiative investigates emotion network dysfunction and anxiety in early Alzheimer's disease, addressing a critical gap in understanding how individuals at risk for cognitive decline deviate from healthy aging patterns. The project employs...
- Federal Grant Award Summary Yale University received a $2.72 million Project Grant award from the National Institute of Environmental Health Sciences under the Medical Library Assistance program (CFDA 93.879) on September 17, 2025, with completion scheduled for August 31, 2029. The project, titled "Supervised Weighted Distances: Patient Similarity to Explain Clinical AI Models," develops algorithms and software tools to enhance the interpretability of complex predictive clinical...
- Federal Project Grant Award Summary Yale University received a $461,313 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective June 1, 2025 through May 31, 2027. The grant supports research investigating the role of cysteine string protein alpha (CSPα) in presynaptic autophagy and its relationship to neurodegeneration. The project will generate scientific knowledge products including characterization of synaptic vesicles, autophagosomes, and...
Yale University received a $711,747 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective June 1, 2026, through May 31, 2028, to develop "Beyond Today," a federated repository-as-a-service (RaaS) infrastructure supporting longitudinal health and disease research across the lifespan. The award funds development of an integrated platform combining a research volunteer registry with dynamic consent capabilities and a longitudinal data repository featuring secure, standards-aligned data harmonization and sharing built on FAIR (Findable, Accessible, Interoperable, Reusable) and trust principles. Additional infrastructure components include federated data management, graduated data governance protocols, and a cloud-based analytic workbench with reusable pipelines and artificial intelligence-ready tools. The two-phase implementation plan initiates with an R61 phase at Yale to develop and deploy a functional prototype tested by three research groups spanning early childhood to older adulthood, with key deliverables including metadata index development, registry-repository integration, governance protocol deployment, and analytic workbench implementation. The subsequent R33 phase extends infrastructure capabilities to Arkansas Children's Research Institute to validate cross-site federation and expand metadata coverage, establishing a scalable platform designed to address fragmentation in health research and enable prospective, multi-modal data collection and reuse across institutions.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $711.7k | 6/3/26 |