Project Grant R61AG094651
- This federal Project Grant award of $372,690, provided by the National Institute on Aging (CFDA 93.866 Aging Research), aims to comprehensively understand the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The key objectives are to: (1) develop new statistical methods for uncovering heterogeneous causal relationships among amyloid-beta, tau accumulation, and cognition across diverse AD datasets; (2) apply these methods to reveal optimal treatment windows and target populations...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support a $185,074 research study conducted by the University of California, Berkeley. The goal of the study is to examine how brain network connectivity is associated with Alzheimer's disease (AD) risk, longitudinal pathology accumulation, and aging. The researchers will use positron emission tomography (PET) imaging and resting-state functional MRI (rs-fMRI) to investigate the mechanisms of how...
- This $2,220,145 federal Project Grant award, funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), aims to optimize and develop novel cell-type-selective adeno-associated virus (AAV) vector technologies to study disease-relevant cell types and neural circuits in mouse models of aging and Alzheimer's disease. The key products and services to be delivered include: Developing enhanced AAV vectors that can genetically target and manipulate specific brain cell...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This federal Project Grant award of $759,095.00, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), will support research to develop a non-invasive, MR image-guided, focused ultrasound-mediated gene delivery strategy to efficiently transfect microglia and inhibit the SHIP-1 protein. The goal is to enhance microglial phagocytosis of amyloid-beta and improve neuronal health to potentially treat Alzheimer's disease. The award will fund the...
- This federal Project Grant award of $3,221,450.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to define how neuronal hyperexcitability in the retrosplenial cortex (RSC) contributes to the development of Alzheimer's disease (AD)-related behavioral deficits in mouse models. The research aims to determine the effect of inhibiting RSC layer 5 cells on spatial memory and navigation, as well as when hyperexcitability emerges in these cells across different AD...
- This federal Project Grant award of $3,080,520.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to develop novel biomarkers for the early detection of Alzheimer's disease and related dementias (ADRD) using resting-state functional magnetic resonance imaging (rs-fMRI) data and machine learning. The research aims to address limitations of current ADRD biomarkers by leveraging the dynamics of functional connectivity networks and accounting for heterogeneity...
- The federal Project Grant award of $3,642,232.00, awarded on August 5, 2025 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to leverage genetics and multi-omic data to identify causal genes, cell types, and molecular mechanisms underlying Alzheimer's disease (AD). The project, titled "UNRAVELING THE GENETIC BASIS OF MOLECULAR FUNCTIONS IN ALZHEIMER'S DISEASE", will integrate multi-ancestry molecular quantitative trait loci (xQTL) data...
- This federal Project Grant award for $528,876, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). The key goals of the project are to: Estimate genome-wide cis- and trans-acting quantitative trait loci (QTLs) effects for transcriptome-wide genes and proteome-wide proteins across 4 brain...
- The National Institute on Aging (NIA) awarded a $1,459,072 project grant to the J. David Gladstone Institutes under the Aging Research Federal Grant Program (CFDA 93.866) to monitor and manipulate inhibitory interneuron cell populations in mouse models of Alzheimer's disease. The 2-year project aims to use dual cell-type-specific enhancer-associated adeno-associated viruses (enhancer-AAVs) to independently monitor and control parvalbumin (PVALB) and somatostatin (SST) inhibitory interneurons...
This federal Project Grant award of $2,316,710 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to develop magnetogenetic techniques for manipulating the activity of specific brain cell types implicated in the onset and progression of Alzheimer's disease (AD). The research will focus on using a magnetogenetic tool called FERIC (Ferritin Iron Redistribution to Ion Channels) in combination with enhancer AAV vectors to non-invasively control the activity of AD-vulnerable neurons and astrocytes across species. This will allow the research team to test cell-type specific hypotheses underlying the accumulation, spread, and clearance of tau proteins, a key pathological hallmark of AD. The award is provided to the University of California, Berkeley and will run from August 1, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.3m | 7/29/25 |