Project Grant K08NS148761
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $769,995 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, awarded August 1, 2025, with completion scheduled for July 31, 2029. This award funds research to elucidate the functional genetic basis of KCNB1 encephalopathy, a rare developmental and epileptic...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $630,414 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025 through July 31, 2030. The award supports fundamental neuroscience research investigating sodium channel dysfunction in brain development, specifically examining how...
- Federal Grant Award Summary Northwestern University received a $874,094 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective August 1, 2025 through July 31, 2030. The research project addresses the pathophysiology of KCNQ2-related disorders, specifically investigating how mutations in the KCNQ2 gene impair the assembly and physiology of...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $634,938 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2026 through May 31, 2031. The award funds basic and translational research investigating RNA editing dysregulation in dementia with Lewy bodies (DLB) and Parkinson's disease (PD)....
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $178,208 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective September 1, 2025, through December 31, 2027. The award supports fundamental neuroscience research investigating the critical role of the mitochondrial enzyme malate dehydrogenase 2 (MDH2) in...
- Federal Project Grant Award Summary Northwestern University received a $1.44 million Project Grant (DP2 mechanism) from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), awarded August 1, 2025, with completion targeted for July 31, 2028. This award supports the development of next-generation RNA precision medicines to treat severe neurodevelopmental diseases, particularly early-onset epilepsy and treatment-resistant seizure...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $630,651 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective June 1, 2026 through May 31, 2031. The grant funds fundamental research to define the molecular architecture and transport mechanisms of CNNM (Cyclin and CBS Domain Magnesium Transport...
- Federal Project Grant Award Summary The University of Chicago received a $121,230 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2027. This award funds research investigating terminal selector functions in motor neurons, with particular focus on the UNC-3 transcription factor in Caenorhabditis...
- Federal Project Grant Award Summary Northwestern University received a $438,606 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025 through July 31, 2027. The research project focuses on establishing induced pluripotent stem cell (iPSC)-based models to investigate the mechanistic interaction between neurotrauma and amyotrophic...
- Federal Project Grant Award Summary Northwestern University's Sponsored Research Division received a $214,329 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award, effective May 6, 2026 through April 30, 2028, funds research investigating infection-driven inflammation as a novel driver of neurodegeneration in primary mitochondrial...
Northwestern University's Sponsored Research Division received a $230,985 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective July 1, 2026 through June 30, 2031. This award supports a comprehensive research initiative to profile and engineer the ion channel transcriptome in the human brain, addressing a critical gap in understanding how alternative splicing of ion channel genes contributes to neurological disorders including autism, epilepsy, and epileptic encephalopathy. The funded research delivers two primary products: (1) comprehensive identification and annotation of ion channel isoforms in the human cerebral cortex using long-read RNA-sequencing and transcript capture technology, with bioinformatic analysis to identify isoforms differentially regulated during postnatal brain development; and (2) functional assessment of alternative splicing impacts on neuronal physiology through a CRISPR-based toolkit developed for human stem cell-derived neurons, using the epilepsy-associated KCNMA1 gene as proof of concept and employing whole-cell patch-clamp electrophysiology to measure changes in neuronal excitability. These research outputs are designed to establish ion channels as viable targets for both small molecule and RNA therapeutic interventions in treating neurological disorders.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $231.0k | 6/3/26 |