This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $429,000.00 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to develop and apply tools for manipulating biomolecular condensates in neurons in order to modulate the properties of the postsynaptic density and assess the functional consequences on synaptic structure and plasticity. The two-year project...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $422,280 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to identify and study novel intracellular proteins that underlie the distinct nanoscopic architecture of the neurexin-1 and neurexin-3 proteins. The project aims to use super-resolution imaging techniques and structure-function analyses to...
This federal Project Grant award of $414,650.00 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports research on the molecular mechanisms regulating the pace of silent synapse maturation and its impact on neural network refinement in the visual cortex. The project, titled "Mechanisms of Silent Synapse Maturation for Excitatory Network Refinement," aims to uncover signaling pathways that govern the balance between...
This Project Grant award of $466,757 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research at the University of Texas at Austin to investigate the synaptic plasticity mechanisms that underlie learning and memory formation in the brain. The key objectives are to understand how the structure and function of synapses, specifically dendritic spines and active zones, dynamically change during the induction and...
The federal Project Grant award R01MH134827, in the amount of $692,043, was provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The grant supports research to investigate the role of presynaptic homeostatic plasticity, a physiological process that stabilizes neural function, and its potential links to the cause and severity of mental health disorders such as autism and intellectual disability. The research conducted under this...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $150,251 to support research on the impact of species-specific synaptic maturation timing on cortical circuit and behavioral development. The principal awardee, The Trustees of Columbia University in the City of New York, will utilize CRISPR/Cas9 approaches and electrophysiology to characterize the morphological and functional maturation of...
The National Institute of Mental Health (NIMH) awarded a $2,048,011 Project Grant (CFDA 93.242 - Mental Health Research Grants) to Baylor College of Medicine. The grant supports research to elucidate the roles of Adhesion G Protein-Coupled Receptors (A-GPCRs), particularly the BAI subfamily, in regulating excitatory synapse development, function, and plasticity in the brain. Key objectives include investigating how BAI receptors sense cellular and molecular cues and relay this information to Rho...
This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), will support research to investigate the compartment-specific functional organization of synaptic inputs along the dendrites of layer 2/3 pyramidal neurons in behaving animals, as well as the mechanisms that shape this organization during learning. The $121,933 award to the University of California, San Diego will fund three specific aims: 1) characterizing...
This $429,000 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to investigate the role of synaptic adhesion molecules in regulating myelination of axons in the central nervous system. The project aims to determine whether the proteins NCAM1, CADM1, and CADM4 guide the formation of myelin sheaths on specific axons, which may contribute to the myelin abnormalities associated with autism...
This Project Grant award of $429,000 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to understand the cellular and synaptic mechanisms underlying cognitive disabilities in Down syndrome. The award to the University of Colorado-Denver will utilize a novel combination of two-photon microscopy, electrophysiology, chemogenetics, and pharmacological...