This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program provides $150,001 to study the individual and collective behavior of osteoclast cells, which play a critical role in bone resorption and remodeling. The project, led by a physician specializing in orthopedic clinical research and a physicist focusing on collective organism dynamics, aims to observe the movement and bone degradation patterns of individual and groups of...
This federal Project Grant award of $588,302 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS, CFDA 93.846 Arthritis, Musculoskeletal and Skin Diseases Research program) will support research by The University of Texas Southwestern Medical Center to investigate the role of glutamine metabolism in regulating osteoclast differentiation and bone resorption. The key objectives are to 1) establish the necessity and sufficiency of glutaminase-dependent glutamine...
This $375,100 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to identify myeloid progenitors that maintain cortical bone with aging and characterize cells/molecules that promote coupling within cortical bone. The goal is to spur the development of new therapeutics to limit age-associated cortical bone loss. The award was made to the...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $652,729 to investigate how the X-linked chromatin modifying enzyme KDM5C regulates bone mass in females. The primary investigators, Dr. Tao Yang and Dr. Connie Krawczyk, will examine how loss of KDM5C affects osteoclast function, communication between osteoclasts and osteoblasts,...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support a comprehensive research study on the role of calcium signaling in 3D osteocyte networks and their influence on the bone's mechanoadaptive response. The $322,408 award, with a project period from August 2024 to July 2029, will enable Syracuse University to utilize a new Bone...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), totaling $599,693, supports research focused on elucidating molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis under pathological inflammatory conditions, with the goal of developing new therapeutic approaches to suppress pathological bone...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a 5-year, $483,070 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Curators of the University of Missouri, doing business as the University of Missouri at Kansas City (UMKC), with an award date of July 18, 2024 and an ultimate completion date of June 30, 2029. The grant will fund research to study the dynamics of bone extracellular matrix (ECM) assembly and...
The University of California, Los Angeles (UCLA) has been awarded a Project Grant of $216,850 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant, which runs from September 1, 2024 to March 14, 2027, will support UCLA's research on the genetic determinants of endoplasmic reticulum (ER) stress in osteogenesis imperfecta (OI) and its consequences on cellular receptors. The...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $626,879 to the University of Southern California to conduct research into the cellular and molecular mechanisms underlying large-scale bone regeneration. The research aims to unravel the intricate processes governing the initiation and coordination of extensive bone repair,...
This $719,873 federal Project Grant award was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The funding supports research to investigate how epigenetic deregulation of osteoblasts (bone cells) in the bone marrow stroma can promote age-related clonal hematopoiesis and contribute to the development of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), particularly in patients with IDH1/2 mutations. The research aims to delineate how...