Project Grant R56EY037749
- This federal Project Grant award of $764,881 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to investigate the role of advanced glycation end products (AGEs) in primary open-angle glaucoma (POAG). The overarching hypothesis is that the accumulation of AGEs in the trabecular meshwork promotes extracellular matrix remodeling and cell dysfunction, leading to increased outflow resistance and elevated intraocular pressure in POAG. The research project has two...
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- The National Eye Institute (NEI) awarded a $451,000 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Regents of the University of California, San Francisco (UCSF) to conduct a multimodal characterization of a novel inherited mouse model of glaucoma. The research aims to evaluate structural and functional changes in the mouse model, including axonal degeneration, retinal ganglion cell loss, dendritic changes, and neuroinflammatory responses. It will also identify...
- This federal Project Grant award of $428,349 from the National Eye Institute's Vision Research program (CFDA 93.867) supports research into the mechanistic assessment of retinal ganglion cell genesis. The award, with a performance period from July 1, 2025 to March 31, 2030, aims to investigate the shared gene regulatory network and downstream targets of the key transcription factors Atoh7, Pou4f2, and Isl1 that are required for proper retinal ganglion cell development. The research will be...
- This Project Grant award of $568,122.00, provided by the National Eye Institute (CFDA 93.867 - Vision Research), supports research at Baylor College of Medicine to unequivocally confirm the contribution of the neurovascular unit to glaucoma pathogenesis and identify endothelial cell-specific ligands with potential for neuroprotective therapy. The research aims to globally map ligands binding to ocular hypertension and healthy retinal cells, systematically identifying ocular...
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $147,486 to The Johns Hopkins University to evaluate the regenerative potential of human retinal ganglion cells (RGCs) for the treatment of eye diseases like glaucoma. The research aims to investigate if modulating intrinsic RGC-expressed factors can promote axonal regeneration, optic nerve regrowth, and restoration of visual function. The award period runs from Jun 1, 2025 to May 31,...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, provides $590,160.00 in funding to characterize photoreceptor precursor cells for retinal transplantation. The research aims to improve understanding of photoreceptor development and investigate avenues for photoreceptor regeneration to restore vision, as retinal degenerative diseases...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- This Project Grant award from the National Eye Institute's (NEI) Vision Research program, with a total funding amount of $618,088, aims to investigate the role of mitochondrial DNA (mtDNA) and the immune sensor protein ZBP1 in retinal neurodegeneration associated with glaucoma. The 4-year research project, running from February 1, 2025 to January 31, 2029, will be led by a multi-PI team at the University of Texas Medical Branch at Galveston. The key objectives are to test the hypothesis that...
- This $439,016 federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) aims to provide initial proof-of-concept for a novel therapeutic approach to glaucoma. The goal is to target the progressive TGFβ2-associated aqueous outflow pathway pathology in a feline model of early onset glaucoma. The project involves optimizing viral vector-mediated transduction of feline trabecular meshwork cells to suppress pathologic TGFβ2 signaling, which contributes to increased...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $1,357,192 to The Trustees of the University of Pennsylvania to conduct research on the impact of WDR36 gene variants and p53 in glaucoma. The research aims to understand how WDR36 variants contribute to primary open-angle glaucoma (POAG) and whether retinal ganglion cells with these mutations respond to gene augmentation therapy. The study will utilize mouse models and human stem cell-derived retinal ganglion cells to investigate the role of the WDR36 WD40 domain in ribosomal assembly, cell survival, and the p53-mediated apoptosis pathway. The award period runs from September 1, 2025 to August 31, 2027 and supports this comprehensive investigation into the genetic factors and potential therapeutic approaches for this leading cause of vision loss.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.4m | 8/25/25 |