Project Grant R56EY036024
- This Project Grant award of $715,000 from the National Eye Institute (CFDA 93.867 - Vision Research) supports research into the mechanisms by which bacterial pathogens use polysaccharide capsules to evade the immune system during ocular infections, a leading cause of blindness worldwide. The research, conducted by the University of Oklahoma Health Sciences Center, aims to investigate how these "cloaking" mechanisms allow antibiotic-resistant ESKAPE group bacteria to proliferate in...
- This $257,785 Project Grant was awarded on April 1, 2025 by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867). The grant supports the development of a refillable micromachined lens capsule-based drug delivery device for extended intraocular delivery of biologics and immune-modulating peptides to treat non-infectious uveitis. The key products/services to be delivered under this 4-year grant include: Characterizing and controlling the release of the...
- The National Eye Institute (NEI), under the federal Vision Research grant program (CFDA 93.867), awarded a $586,258 project grant to Wayne State University to characterize the role of eosinophils in modulating the corneal response to Pseudomonas aeruginosa-induced infection. The 4-year project, commencing on July 1, 2025 and completing on April 30, 2029, aims to investigate the spatiotemporal distribution, phenotypic profiles, and proteomic changes of eosinophils during corneal infection. The...
- The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $321,904 Project Grant to Proteris Biotech, Inc. through the Vision Research federal grant program (CFDA 93.867). The award, spanning August 1, 2025 to July 31, 2026, will fund the early development of the natural tear protein clusterin (CLU) as a novel approach to treat dry eye disease. The research aims to conduct non-GMP stability analysis of the drug substance and product, as well as perform...
- The National Eye Institute (NEI), part of the Department of Health and Human Services, awarded a $113,274 Project Grant to the Texas A&M University System Health Science Center (TAMU HSC) under the Vision Research federal grant program (CFDA 93.867). The grant, awarded on June 1, 2025, aims to develop innovative surgical techniques using ultrafast, nonthermal lasers for treating vitreoretinal and posterior segment disorders of the eye. The project will evaluate the use of femtosecond...
- The National Eye Institute (NEI) awarded a $673,747 Project Grant to New York University (NYU) for the "Visible-to-Near-Infrared Spanning Optical Coherence Tomography for Retinal Imaging at the Half-Micron Scale" research project under the NEI's Vision Research program (CFDA 93.867). The grant aims to develop advanced optical coherence tomography (OCT) techniques to enable more accurate in vivo measurement and localization of macular pigments and retinal pigment epithelium melanosomes,...
- The National Eye Institute (NEI) awarded a $421,136 Project Grant to the University of Maryland, College Park under the Vision Research federal grant program (CFDA 93.867) to explore a novel approach for correcting ocular opacities and enabling high-resolution fundus imaging. The 2-year project aims to demonstrate that neural-network based wavefront shaping can optically correct for ocular opacities, which degrade the performance of optical imaging techniques for the posterior segment of the...
- This $231,000 Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), will fund the development of a generalized deep learning platform to improve the objectivity, reproducibility, and accuracy of quantifying and assessing experimental autoimmune uveitis (EAU) - a valuable animal disease model for studying human uveitis. The project aims to generate high-quality, well-annotated multi-modal datasets from three independent research...
- The National Eye Institute (NEI) awarded a $312,239 Project Grant under the Vision Research federal grant program (CFDA 93.867) to Shift Pharmaceuticals Holdings, Inc. for the development of an antisense oligonucleotide (ASO) therapeutic to inhibit retinoic acid signaling and mitigate vision loss in retinitis pigmentosa and age-related macular degeneration. The project aims to create a targeted ASO therapy that can block the production of retinoic acid receptors at the cellular level within...
- The National Eye Institute (NEI) awarded a Project Grant of $433,125 to The Ohio State University (OSU) to investigate tissue factor (TF) as a potential biomarker and therapy for corneal neovascularization (CNV), a leading cause of blindness worldwide. The grant, under the NEI's Vision Research program (CFDA 93.867), aims to inhibit the growth of abnormal blood vessels in the cornea through targeting TF. The research efforts at OSU will explore TF's role in CNV and develop an immunoconjugate...
The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $693,423 Project Grant on September 15, 2025 to the University of Mississippi Medical Center (UMMC) to develop a multivalent antibody cocktail for the treatment of bacterial endophthalmitis. The goal of this 1-year project is to translate prior research on ocular microbiology into a new drug that can be used in conjunction with antibiotics to combat damage and loss of retinal function caused by the top three bacterial causes of endophthalmitis: Coagulase-negative Staphylococci, Staphylococcus aureus, and Streptococcus pneumoniae. The project is funded under the NEI's Vision Research program (CFDA 93.867), which supports comprehensive research to understand, prevent, and treat vision-related conditions and diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $693.4k | 9/11/25 |