This $698,646 federal Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to study the functional and disease relevance of distinct pancreatic beta-cell subtypes, with a focus on understanding their epigenetic regulation and relationship to type 2 diabetes (T2D). The research will use novel single-cell epigenomic tools, conditional...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $194,616 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Weill Medical College of Cornell University. The grant aims to examine the impact of in vivo activation of the transcription factor ATF6 on pancreatic beta cell function, specifically in relation to insulin production and secretion. The research will contribute to the understanding of the...
This federal Project Grant award, valued at $567,643.00 and spanning September 2024 through May 2029, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Duke University focused on understanding the communication between alpha and beta cells, and its role in insulin secretion and glucose homeostasis, particularly in the context of...
The federal Project Grant award R01DK139146, titled "Reprogramming Glutamine Metabolism in Pancreatic Beta Cells", is funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The $1,349,491 award supports research to uncover the mechanisms by which the transaminase GPT2 promotes pancreatic beta cell dysfunction and death, and how GPT2 influences the sensitivity of...
This federal Project Grant award for $249,000.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will fund research to characterize the role of m6A mRNA methylation in the aging of B-cells and its contribution to the development of type 1 and type 2 diabetes. Key objectives include: 1) Characterizing the temporal m6A landscape of the aging B-cell,...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Brigham Young University a $568,075 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to determine the role of the NR4A1 protein in regulating the GLP-1R and DYRK1A pathways, which are critical for expanding functional beta-cell mass as a potential treatment for type 1 and type 2 diabetes. The research aims to elucidate the...
This $174,368 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research conducted by the University of Michigan to investigate the role of the LRRK2 protein in pancreatic beta cell responses to inflammatory damage. The research aims to provide novel insights into the mechanisms governing beta cell survival during inflammatory challenges, which...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,338,684 to Yale University to conduct a longitudinal study utilizing PET and MRI techniques. The goal is to assess insulin vesicle functional capacity, beta cell mass, and pancreas volume in individuals at risk for and with recent onset type 1 diabetes. The study aims to...
This $205,280 Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports a research project investigating the mechanisms driving the kinetics of incretin-mediated beta cell responses. The project aims to quantify the trafficking of incretin receptors and their influence on cAMP responses, as well as examine the interplay between cAMP and...
This Cooperative Agreement award of $1,232,846.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports the development of a vascularized micro-organ platform to study the mechanisms of beta cell death in type 1 diabetes. The key objectives are to: 1) Build a histocompatible system using induced pluripotent stem cells (iPSCs) from type 1 diabetes patients and...