This $675,480 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to develop a novel therapeutic compound for treating chronic kidney disease (CKD). The awardee, Fibrotherapeutics Inc., is conducting preclinical studies to evaluate the efficacy, safety, and therapeutic index of a modified, water-soluble, orally-active peptide derived...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,152,592 to the University of California, Los Angeles (UCLA) to conduct research on the mechanisms by which iron deficiency worsens inflammatory tissue injury. The project aims to define the molecular pathways underlying the adverse interaction between iron deficiency and...
This $400,000 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the earliest events in podocyte injury in collagen IV nephropathies. The goal is to investigate how processing of mutant collagen IV proteins injures podocytes at early stages, leading to chronic kidney disease and renal failure. The research uses...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $2,202,378 to the Icahn School of Medicine at Mount Sinai to conduct research on the protective role of the KLF2 gene in diabetic kidney disease (DKD). The key goals are to determine how KLF2 is regulated in diabetic conditions, how it protects against glomerular endothelial...
This $820,119 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research focused on elucidating the mechanobiological functions of novel cytoskeletal structures in podocytes to reveal new therapeutic opportunities for kidney glomerular diseases. The primary research aims to better understand the mechanisms underlying podocyte homeostasis,...
This Project Grant award of $128,286 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the underlying cellular mechanisms of lipotoxicity in kidney tubular epithelial cells and its contribution to the development of chronic kidney disease (CKD). The principal investigator at The Broad Institute, Inc. aims to describe the mechanism by...
This $1,149,974 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to investigate the central role of red blood cell (RBC) trapping in mediating ischemic acute kidney injury (AKI). The primary awardee, Augusta University Research Institute, Inc., will conduct studies to test the hypotheses that RBC trapping induces tubular injury and heme toxicity, leading...
The University of Illinois received a $1,695,959 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) to perform kidney functional magnetic resonance imaging (fMRI) on 420 participants with chronic kidney disease (CKD) recruited from 7 sites. The goal is to test the associations of kidney fMRI biomarkers with chronic histopathologic lesions and changes in kidney function over time. The...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...
This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...