Project Grant R56DE035844
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Minnesota a $649,046 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) beginning June 1, 2026, and concluding February 28, 2031. This award funds basic research investigating the microbial mechanisms by which Streptococcus gordonii, a pioneer colonizer bacterium, shapes early dental plaque biofilm community development and...
- Summary of Federal Project Grant Award The National Institute of Dental and Craniofacial Research (NIDCR) awarded $320,660 to the University of Illinois (Chicago) under the Oral Diseases and Disorders Research program (CFDA 93.121) on April 6, 2026, to support research investigating the immunoregulatory role of dendritic cell (DC) subsets in periodontal disease. The research focuses on elucidating how three major DC subsets—myeloid DC (MDC), lymphoid DC (LDC), and plasmacytoid DC...
- Federal Grant Award Summary Award Details: The National Institute of Dental and Craniofacial Research (NIDCR) awarded Augusta University Research Institute, Inc. a Project Grant totaling $645,009 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award period runs from June 15, 2025, through June 14, 2027. Research Scope: This grant funds a research project investigating the molecular mechanisms of alveolar bone loss in periodontitis through examination of...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $620,000 to the University of Minnesota's Office of Sponsored Projects Administration under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 1, 2025, for a two-year project period concluding May 31, 2027. This Project Grant supports research to identify and characterize natural products synthesized by Streptococcus mutans that demonstrate antimicrobial and...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Michigan a Project Grant of $429,000 under the Oral Diseases and Disorders Research program (CFDA 93.121), with an award date of June 5, 2026, and a completion date of June 8, 2028. This research initiative investigates the long-term effects of recurrent periodontitis on hematopoietic stem cell (HSC) function and systemic health outcomes. The University of...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $435,875 to Indiana University Indianapolis through its Oral Diseases and Disorders Research program (CFDA 93.121) on July 15, 2026, for a two-year project concluding July 14, 2028. The project, titled "PERIOX - Peri Implant Oxylipin Mediated Biofilm Colonization," will conduct exploratory research to elucidate the mechanisms by which bacterial biofilms form and persist around...
- Federal Grant Award Summary Baylor College of Medicine received a $453,797 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 5, 2026, with a completion date of June 4, 2028. The research project investigates the structures and functions of natural products in periodontal disease, specifically examining novel biosynthetic gene clusters found in clinical isolates of...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded University of California, Los Angeles $180,943.00 under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 13, 2025, for research addressing therapeutic targeting of apical periodontal T-cells in chronic oral inflammation. The research initiative, which extends through May 31, 2030, investigates the pathogenic mechanisms underlying apical periodontitis—a chronic...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a $568,759 Project Grant (CFDA 93.121: Oral Diseases and Disorders Research) effective May 1, 2026, through April 30, 2031, to conduct basic research on pathogen synergy and immune subversion in periodontal disease. The research deliverables include scientific investigations of how two gram-negative anaerobic...
- Federal Grant Award Summary The University of Minnesota, through its Office of Sponsored Projects Administration, received a five-year Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) totaling $405,911, effective July 1, 2026 through June 30, 2031. The award funds the Minnesota Dental, Oral and Craniofacial Training in Research (MN-DOCTR) T32 program, which provides structured research...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Minnesota a Project Grant totaling $609,498 under the Oral Diseases and Disorders Research program (CFDA 93.121). The award, effective July 8, 2026, through July 7, 2028, funds research to investigate the role of inducible T cell co-stimulator (ICOS)-Fc in modulating the inflammatory response and bone loss associated with periodontitis. The research will utilize a murine model of ligature-induced periodontitis to characterize how ICOS-Fc affects T cell expansion, macrophage polarization, osteoclast activity, and alveolar bone resorption. The deliverables from this project include scientific findings on the mechanisms by which ICOS-Fc prevents the interaction of ICOS ligand (ICOSL) with ICOS-expressing T cells while simultaneously activating ICOSL signaling on endothelial cells and macrophages. The research aims to generate data demonstrating whether ICOS-Fc reduces inflammatory cell expansion, promotes alternative macrophage activation, and mitigates osteoclast-mediated bone loss, thereby contributing to the understanding of potential therapeutic approaches for periodontitis treatment and periodontal healing.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $609.5k | 7/9/26 |