This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $294,505 to support the development and commercialization of a targeted fluorescence dye for intraoperative imaging and precision surgical treatment of head and neck cancer (HNC). The goal is to create a small peptide-based fluorescent probe that can specifically stain HNC tumors to assist surgeons in identifying tumors...
This Project Grant award of $466,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop near-infrared chemiluminescent and fluorescent (NIR CFL) chitosan-based nanoparticles (CNPs) to improve the detection of micrometastatic cancer and guide image-guided surgery. The nanoparticles can be activated by body heat and stored at low temperatures for convenience and safety. The research...
This $550,296 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a multimodal imaging diagnostic platform to improve risk assessment of precancerous oral lesions. The key products and services to be delivered under this grant include: Development of machine learning and deep learning models using Fourier transform infrared (FTIR) imaging techniques for risk...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a noninvasive ultrasound-based molecular imaging tool to identify small metastases in the lymph nodes of head and neck cancer patients. The $1,352,406.84 grant will fund the development of perfluorocarbon nanodroplet contrast agents targeted to cancer cell surface receptors, which can be visualized using...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $619,347 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to Light Research Inc. (LRI), a for-profit small business in Tucson, Arizona. The grant supports the optimization and commercialization of a compact multimodal intraoral camera that integrates polarized white light imaging, autofluorescence imaging, optical coherence tomography, and near-infrared transillumination imaging modalities. This...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $2,805,385 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Oregon Health & Science University (OHSU). The grant will fund research to define T cell-based mechanisms of oral mucosal immune-related adverse events (irAEs) from anti-PD-1 cancer immunotherapy, with the goal of identifying predictive markers and strategies to mitigate these toxicities. OHSU will collaborate with...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop an intraoral camera system that can detect and monitor early-stage dental caries (tooth decay) using targeted fluorescent nanoparticle technology and AI-assisted imaging analysis. The $294,632 award to Greenmark Biomedical Inc. will fund the development of a minimally viable product (MVP) of the intraoral camera...
This $1,403,398 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) aims to utilize advanced imaging approaches to develop a set of imaging-based biomarkers for head and neck squamous cell carcinoma (HNSCC) based on the hybrid epithelial/mesenchymal (HEM) state and its interactions with the immune system. The primary objectives are to: 1) further define the effect of HEM on immune...
This $381,100 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development and evaluation of tumor-targeting polymeric micelles carrying a near-infrared (NIR) imaging agent. The goal is to provide real-time optical image guidance during brain cancer surgery to improve tumor resection and surgical outcomes. The project aims to: 1) develop and characterize the tumor-targeting polymeric...
This $598,332 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the role of the truncated TrkB isoform (TrkBT1) in oral cancer pain. The primary awardee, the University of Texas Health Science Center at San Antonio (UTHSCSA), will conduct studies to examine how TrkBT1 expressed in trigeminal sensory neurons and oral squamous cell carcinoma (OSCC)...