This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $2,090,579.68 to develop a noninvasive ultrasound-based molecular imaging tool to identify micrometastases in the lymphatics of head and neck cancer patients. The project aims to create perfluorocarbon nanodroplet contrast agents targeted to cell surface receptors, enabling the detection of small pockets of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $294,505 to support the development and commercialization of a targeted fluorescence dye for intraoperative imaging and precision surgical treatment of head and neck cancer (HNC). The goal is to create a small peptide-based fluorescent probe that can specifically stain HNC tumors to assist surgeons in identifying tumors...
This federal Project Grant award of $374,095 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a device that uses an infrared laser to enable local delivery of a high dose of chemotherapy to the surgical cavity after tumor resection. The technology employs thermosensitive liposomal nanoparticles encapsulating chemotherapy agents that...
The University of Colorado-Denver was awarded a $375,134 Project Grant from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to investigate a novel approach for reducing off-target accumulation of chemotherapeutic nanomedicines. The key objectives are to characterize the innate immune response that can tighten epithelial barriers and limit nanoparticle deposition in healthy tissues, and to leverage this response to enhance delivery of chemotherapeutic agents to tumors...
This federal Project Grant award of $274,100.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to advance understanding of pain signaling and drug delivery for treating oral cancer pain. The key objectives are to: Determine the impact of oral cancer on the trafficking and signaling of the protease-activated receptor 2 (PAR2) in trigeminal neurons. This will involve investigating changes in PAR2...
This $381,100 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development and evaluation of tumor-targeting polymeric micelles carrying a near-infrared (NIR) imaging agent. The goal is to provide real-time optical image guidance during brain cancer surgery to improve tumor resection and surgical outcomes. The project aims to: 1) develop and characterize the tumor-targeting polymeric...
This $550,296 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a multimodal imaging diagnostic platform to improve risk assessment of precancerous oral lesions. The key products and services to be delivered under this grant include: Development of machine learning and deep learning models using Fourier transform infrared (FTIR) imaging techniques for risk...
This federal Project Grant award of $429,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to determine the functional roles and mechanisms of the human microbiome and metabolome in the pathogenesis of oral squamous cell carcinoma (OSCC), a prevalent and lethal form of head and neck cancer. The research aims to 1) define OSCC-associated metagenomic and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $620,592 to Oregon Health & Science University (OHSU) to develop novel short-wave infrared (SWIR) fluorophores for improved visualization of buried facial nerves during head and neck cancer surgery. The goal is to create a first-in-class SWIR nerve-specific contrast agent that can enhance intraoperative...
This federal Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) supports the development of a new bio-orthogonal mid-infrared photothermal imaging approach to quantitatively measure various molecular events in cancer cells at the subcellular level. The $407,113 award to Trustees of Boston University will be used to: 1) build a library of nitrile-based probes to sense important molecular events inside cancer cells; 2) develop...
This Project Grant award of $466,500.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop near-infrared chemiluminescent and fluorescent (NIR CFL) chitosan-based nanoparticles (CNPs) to improve the detection of micrometastatic cancer and guide image-guided surgery. The nanoparticles can be activated by body heat and stored at low temperatures for convenience and safety. The research will assess the ability of these CNPs, conjugated with synthetic targeting ligands, to enhance tumor targeting and evaluate surgical margins and metastatic lymph nodes using chemiluminescence and fluorescence optical imaging. The anticipated outcomes include advancing the combined use of optical imaging, enabling improved detection of micrometastatic disease, reducing surgical morbidity, and providing valuable guidance for cancer patient management decisions. The award is to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, and will be conducted over a 3-year period from September 2024 to September 2027.