This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA 93.213 - Research and Training in Complementary and Integrative Health provides $451,000.00 in funding to The Trustees of Princeton University from September 2024 to August 2026. The objective is to characterize the secondary metabolomes of three Corynebacterial strains, including uncovering the small molecule products they use to compete with other microbes and interact with host cells....
This $422,931 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will fund research to characterize how specialized metabolites mediate interactions within the human microbiome, with the goal of understanding how these metabolite-driven community dynamics influence susceptibility to antimicrobial therapies. The research will integrate cheminformatics analysis of...
The National Center for Complementary and Integrative Health (NCCIH), under the Federal Grant Program "Research and Training in Complementary and Integrative Health" (CFDA 93.213), awarded a $340,449 Project Grant to Brown University to conduct research aimed at alleviating antibiotic-induced disruption of the gut microbiome. The research project, titled "Alleviating Antibiotic-Induced Microbiome Dysfunction by Quenching the Microbial Redox Environment," seeks to identify...
This federal Project Grant award of $295,780.00, funded by the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), supports the development of a high-throughput in vivo screening platform to identify novel probiotic and postbiotic bacterial strains. The awardee, Nemalife Inc., will leverage the nematode Caenorhabditis elegans as a model organism to rapidly screen and characterize bacterial...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA Program 93.213 - Research and Training in Complementary and Integrative Health, provides $506,000.00 in funding to the Scripps Research Institute in La Jolla, CA from September 13, 2024 to August 31, 2026. The award supports research to develop orally available recombinant peptidoglycan hydrolase therapeutics that can promote intestinal barrier function and protect against enteric...
This $2,279,811 Project Grant, awarded by the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), aims to transform the functional characterization of the gut microbiome. The grant supports the development of novel activity-based probes (ABPs) to directly measure enzymatic function and microbial mechanisms within the complex gut microbiome. The research will utilize both gnotobiotic mouse models and longitudinal cohorts of...
This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), is focused on elucidating the mechanisms by which gut microbiome dysbiosis impacts the transport of short-chain fatty acids (SCFAs) and its relevance to autoimmune disorders like multiple sclerosis (MS). The $863,500 award, spanning September 2024 to August 2026, will investigate how MS-associated gut...
The National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health federal grant program (CFDA 93.213), has awarded Oregon State University a $141,354 project grant to investigate bioactive natural products from estuarine sediment microbial communities. The key objectives are to: 1) sample estuarine sediments in Oregon using adsorbent resin collectors and sediment scoops to extract metabolites and analyze microbial...
This $325,139 federal Project Grant award, funded by the National Center for Advancing Translational Sciences (NCATS), 93.350 program, aims to examine the feasibility of using target-specific polyclonal antibodies to neutralize bioactive molecules in the gut microbiome. The primary goals are to 1) determine the impact of six proteins identified as overabundant in inflammatory gut disorders, and 2) evaluate the ability of immunoglobulin Y (IgY) antibodies to neutralize the physiological impacts...
This $1,132,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research by the Engevik Lab at the Medical University of South Carolina (MUSC) to investigate the complex interactions between gut microbiota and intestinal mucus. The overarching goal is to unravel the mechanisms by which commensal gut bacteria respond to and stimulate mucus production, which plays a vital role in...