This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $526,174 to Duke University to engineer heterocellular human skeletal muscle tissues. The goal is to recreate and study the native stem cell niche function of healthy skeletal muscle, which is critical for its regenerative capacity. By incorporating capillary networks and functional...
This Project Grant award of $3,161,352 from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a 5-year investigation into the molecular mechanisms underlying the effects of aerobic exercise on peripheral and cerebrovascular function in adults of different ages and sexes. The study will examine age and sex differences in the transcriptomic, proteomic, and metabolomic signatures associated with the benefits of chronic exercise training on vascular endothelial function. It...
This Project Grant award of $248,724.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research to investigate the role of cellular senescence in skeletal muscle loss and dysfunction. The primary objectives are to: 1) obtain experimental skills and career training to develop a translational research program on mechanisms underlying skeletal muscle wasting,...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $434,793 to the University of Arkansas to conduct research into regenerative and rehabilitation strategies to reduce inflammation following volumetric muscle loss injury. The research aims to determine the optimal exercise regimen to enhance muscle recovery, as well as investigate the use...
This Project Grant award of $1,034,838 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the regulation of muscle stem cell niches and their role in skeletal muscle regeneration. The overarching goal is to investigate the physiological function of neutrophil serine proteases in the muscle stem cell niche and decipher the underlying molecular...
This $193,188 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) aims to investigate the role of mitochondrial permeability transition (MPT) in skeletal muscle dysfunction and systemic inflammation in sepsis. The central hypothesis is that knockout of the MPT-promoting protein cyclophilin D in skeletal muscle will attenuate both muscle...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under CFDA Program 93.846 Arthritis, Musculoskeletal and Skin Diseases Research, is providing $1,469,862 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the biological and material mechanisms by which exercise controls bone quality. The award period is from September 5, 2024 to August 31, 2029. The key products and services to be...
This $1,294,013 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a multi-year clinical trial and associated research examining the impact of biological aging mechanisms on exercise response variability in older adults. The principal investigator will conduct a randomized trial of a 6-month resistance training intervention and a health education control, focusing on two co-primary outcomes: physical function and insulin sensitivity. The project will...
This federal Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), supports research into the functional roles of microRNA-320 in skeletal muscle. The $374,204 award to The Leland Stanford Junior University will be used to characterize the phenotype of a muscle-specific microRNA-320 knockout mouse model, investigate the underlying molecular...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $201,960 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Vermont & State Agricultural College (UVM) to support research on skeletal myosin-binding protein C (MyBP-C) and its role in modulating muscle contractility. The research aims to create a novel "designer MyBP-C" zebrafish model system to investigate how individual MyBP-C isoforms...