This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $599,693 to support research into the negative regulation of osteoclastogenesis - the process of generating bone-resorbing cells. The overarching goals are to elucidate the molecular pathways and mechanisms that regulate myeloid cell function and osteoclastogenesis under...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $212,574 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Seattle Children's Hospital. The grant supports a mentorship program led by Dr. Shaun Jackson, an established pediatric autoimmunity researcher, to train junior scientists in patient-oriented research at the intersection of pediatric rheumatology and autoimmune kidney disease. The program...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $196,460 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to the University of Pittsburgh. The purpose of this 30-month grant, with a start date of January 30, 2025, is to develop and utilize a novel microphysiological system to study neuro-immune interactions that contribute to osteoarthritis (OA) pain. The research aims to: 1) understand how inflammatory molecules from...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $378,250 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Children's Hospital of Philadelphia (CHOP) Research Institute. The project aims to assess and delineate the mechanisms underlying growth plate dysfunction, a major contributor to skeletal growth and regeneration issues in certain pediatric pathologies. The research will utilize transgenic mouse models,...
The federal Project Grant award of $589,255, issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support research to develop small RNA targeting approaches for treating heterotopic ossification (HO). The project aims to: (I) test new nanoparticle-based strategies to treat HO, which involves pathological bone formation in soft tissues, and (II) advance the...
This $548,828 Project Grant was awarded on September 21, 2023 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant was awarded to Knoubis Bio Inc., a for-profit organization based in California, to support research on a non-immunosuppressive disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis. The project aims to develop a new therapeutic approach...
This federal Project Grant award of $623,628 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research to investigate the epigenetic regulation of human osteogenesis mediated by long non-coding RNAs (lncRNAs). The research aims to mechanistically characterize how specific lncRNAs control chromatin organization and gene expression to initiate and sustain...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $297,940 to Case Western Reserve University to develop patient-driven outcome measures and finalize the design of N-of-1 clinical trials to evaluate therapies for childhood Sjogren's disease. The grant aims to address the lack of pediatric-specific clinical trials and outcome...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $194,700.00 to Boston Children's Hospital to conduct research on the biobehavioral basis and outcomes of cognitive dysfunction in childhood-onset systemic lupus erythematosus (cSLE). The study aims to characterize the functional brain properties, white matter microstructure, and...
This federal Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), is focused on building a comprehensive data repository to collect and share bone phenotyping data from rodent animal models. The total award amount is $522,334.00, with a project period from September 2024 through July 2028. The key products and services to be delivered include:...