The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,037,340 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the Broad Institute, Inc. The grant aims to transform the Musculoskeletal Knowledge Portal (MSKKP) into an established biomedical knowledgebase that integrates curated 'omics datasets, processes them through analytical pipelines, and presents the results through web-based visualizations. The...
This federal Project Grant award, valued at $626,879.00, was awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to explore a novel mouse model of large-scale bone regeneration to unravel the cellular and molecular mechanisms governing the initiation and coordination of bone repair following extensive injuries. Specifically, the research will...
This $483,070 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under CFDA 93.846 "Arthritis, Musculoskeletal and Skin Diseases Research" supports research into the dynamics of bone extracellular matrix (ECM) assembly and resorption. The study aims to investigate how osteogenic cellular dynamics, differentiation, and cell fate are integrated with collagen assembly and mineralization, as well as how osteoclast bone resorption...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will fund research to investigate the mechanisms by which mechanical and hormonal signals are integrated within bone cells to stimulate bone formation. The total award amount is $175,948 and will be performed over 5 years from June 1, 2025 to May 31, 2030. The research aims to identify how the focal...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $220,224 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to The Regents of the University of Colorado, operating as the University of Colorado, with a period of performance from July 4, 2024 to August 31, 2027. The funding will support the development of granular hydrogels for the controlled delivery of immunomodulatory and angiogenic extracellular vesicles to enhance...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $1,066,302 to create a knowledgebase to promote and facilitate the use of the Osteoarthritis Initiative (OAI) to accelerate discoveries. The knowledgebase will extract, accumulate, organize, annotate, and link information related to the OAI, a 16-year observational study with...
This federal Project Grant award of $456,808.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) is supporting the development of advanced mass spectrometry imaging (MSI) technologies to spatially visualize proteins and glycans in musculoskeletal tissues. The primary awardee, the Buck Institute for Research on Aging, is collaborating with researchers at the University of...
This Project Grant award, ID R21AR084126, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The $783,176 award supports research to develop and validate a quantitative spine imaging methodology using photon-counting detector CT (PCD-CT) technology to comprehensively characterize bone quality, including cortical and trabecular microstructures, in patients with...
This federal Project Grant award, valued at $1,938,605.00 and awarded on August 19, 2024 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), aims to define the mechanisms by which the X-linked chromatin modifying enzyme KDM5C regulates bone mass in females. The primary objectives are to investigate how the loss of KDM5C affects osteoclast function, osteoclast-osteoblast communication, and osteoclast energy metabolism. The research team will also examine the...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $206,023 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Cornell University to investigate mechanotransduction pathways in injured cartilage. The project aims to determine how local peak strain magnitude and manipulation of calcium-dependent signaling or mitochondrial bioenergetics affect the distribution of chondrocyte phenotypes after impact injury, using a novel...